THRB

Gene

thyroid hormone receptor beta

HGNCHGNC:11799 EnsemblENSG00000151090 NCBI Gene7068

Locus: gene with protein productLocation: 3p24.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Thyroid hormone receptor betaP10828

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Member of “Receptors, Thyroid Hormone” · 7 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asERBA2 · PRTH · THRB1 · THRB2 · NR1A2 · THR1 · ERBA-BETA · GRTH · TRbeta · TRb · c-erbA-beta · c-erbA-2 · THRbeta · TRbeta1 · THRbeta1 · Thrbeta2

View full nomenclature history (25)

Previous symbolsERBA2, PRTH

Alias symbolsTHRB1, THRB2, NR1A2, THR1, ERBA-BETA, GRTH, TRbeta, TRb, c-erbA-beta, c-erbA-2, THRbeta, TRbeta1, THRbeta1, Thrbeta2

Previous namesthyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2), pituitary resistance to thyroid hormone, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian), thyroid hormone receptor, beta

Alias namesavian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, oncogene ERBA2, generalized resistance to thyroid hormone, thyroid hormone receptor beta 1, nuclear receptor subfamily 1 group A member 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Selective pituitary resistance to thyroid hormone

Thyroid Hormone Resistance Syndrome

Thyroid hormone resistance, generalized, autosomal dominant

Glycogen storage disease due to glycogen branching enzyme deficiency

Thyroid hormone resistance, generalized, autosomal recessive

Hypothyroidism

Non-alcoholic Fatty Liver Disease

Differentiated thyroid carcinoma

Hyperthyroidism

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Thyroid hormone receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.