TNFRSF8

Gene

TNF receptor superfamily member 8

HGNCHGNC:11923 EnsemblENSG00000120949 NCBI Gene943

Locus: gene with protein productLocation: 1p36.22

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tumor necrosis factor receptor superfamily member 8P28908

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCD30 · D1S166E · KI-1

View full nomenclature history (4)

Previous symbolsCD30, D1S166E

Alias symbolsKI-1

Previous namestumor necrosis factor receptor superfamily, member 8

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hodgkin's Disease

Asthma

Anaplastic large cell lymphoma

Respiratory Tract Diseases

Lymphoma, Non-Hodgkin's

Hypersensitivity

Venous Thrombosis

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesTumor necrosis factor receptor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.