TNFSF10

Gene

TNF superfamily member 10

HGNCHGNC:11925 EnsemblENSG00000121858 NCBI Gene8743

Locus: gene with protein productLocation: 3q26.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tumor necrosis factor ligand superfamily member 10P50591

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTRAIL · Apo-2L · TL2 · CD253 · TANCR

View full nomenclature history (6)

Alias symbolsTRAIL, Apo-2L, TL2, CD253, TANCR

Previous namestumor necrosis factor (ligand) superfamily, member 10

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Gout

Triple Negative Breast Neoplasms

Cholelithiasis

Prostate carcinoma

Pericarditis

Carcinoma, Renal Cell

Glioblastoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesTumor necrosis factor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-01-15.

Open TargetsGene–disease associations from the Open Targets Platform.