TNFSF9

Gene

TNF superfamily member 9

HGNCHGNC:11939 EnsemblENSG00000125657 NCBI Gene8744

Locus: gene with protein productLocation: 19p13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tumor necrosis factor ligand superfamily member 9P41273

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known as4-1BB-L · 4-1BBL · CD137L

View full nomenclature history (7)

Alias symbols4-1BB-L, 4-1BBL, CD137L

Previous namestumor necrosis factor (ligand) superfamily, member 9

Alias namesreceptor 4-1BB ligand, homolog of mouse 4-1BB-L, CD137 ligand

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Amyotrophic Lateral Sclerosis

Depressive Disorder

Neoplasms

Neurodegenerative Diseases

Pancreatic Neoplasms

Melanoma

Colonic Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Tumor necrosis factor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.