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TOE1

Gene

target of EGR1, exonuclease

HGNCHGNC:15954EnsemblENSG00000132773NCBI Gene114034
Locus: gene with protein productLocation: 1p34.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known ashCaf1z · TOE-1
View full nomenclature history (3)
Alias symbolshCaf1z, TOE-1
Previous namestarget of EGR1, member 1 (nuclear)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Adenomatous Polyposis Coli
Inherited cancer-predisposing syndrome
Neoplastic Syndromes, Hereditary
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers CCCH-typePARN exonuclease family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.