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TPP1

Gene

tripeptidyl peptidase 1

HGNCHGNC:2073EnsemblENSG00000166340NCBI Gene1200
Locus: gene with protein productLocation: 11p15.4

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCLN2 · SCAR7 · LPIC · TPP-1
View full nomenclature history (9)
Previous symbolsCLN2, SCAR7
Alias symbolsLPIC, TPP-1
Previous namesceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease), spinocerebellar ataxia, autosomal recessive 7, tripeptidyl peptidase I
Alias namesTPP I, lysosomal pepstatin-insensitive carboxypeptidase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neuronal Ceroid-Lipofuscinoses
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.