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TRMU

Gene

tRNA mitochondrial 2-thiouridylase

HGNCHGNC:25481EnsemblENSG00000100416NCBI Gene55687
Locus: gene with protein productLocation: 22q13.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTRMT · MTO2 · FLJ10140 · MTU1
View full nomenclature history (7)
Previous symbolsTRMT
Alias symbolsMTO2, FLJ10140, MTU1
Previous namestRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Alias namesmitochondrial tRNA-specific 2-thiouridylase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Genetic Diseases, Inborn
Mitochondrial Diseases
Sjogren's Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.