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VHL

Gene

von Hippel-Lindau tumor suppressor

HGNCHGNC:12687EnsemblENSG00000134086NCBI Gene7428
Locus: gene with protein productLocation: 3p25.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asVHL1
View full nomenclature history (3)
Alias symbolsVHL1
Previous namesvon Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase, von Hippel-Lindau syndrome

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

von Hippel-Lindau Disease
Pheochromocytoma
Carcinoma, Renal Cell
Neoplastic Syndromes, Hereditary
Inherited cancer-predisposing syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.