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WAS

Gene

WASP actin nucleation promoting factor

HGNCHGNC:12731EnsemblENSG00000015285NCBI Gene7454
Locus: gene with protein productLocation: Xp11.23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Actin nucleation-promoting factor WASP42768

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIMD2 · THC · WASP · WASPA
View full nomenclature history (8)
Previous symbolsIMD2, THC
Alias symbolsWASP, WASPA
Previous namesthrombocytopenia 1 (X-linked), Wiskott-Aldrich syndrome (eczema-thrombocytopenia), Wiskott-Aldrich syndrome
Alias nameseczema-thrombocytopenia

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Wiskott-Aldrich Syndrome
Lymphoma
Severe congenital neutropenia
Genetic Diseases, Inborn
Melanoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Wiskott-Aldrich Syndrome protein family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.