XDH

Gene

xanthine dehydrogenase

HGNCHGNC:12805 EnsemblENSG00000158125 NCBI Gene7498

Locus: gene with protein productLocation: 2p23.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Xanthine dehydrogenase/oxidaseP47989

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asXOR · XO · XDH/XO

View full nomenclature history (7)

Alias symbolsXOR, XO, XDH/XO

Previous namesxanthene dehydrogenase

Alias namesxanthine dehydrogenase/oxidase, xanthine oxidase, xanthine oxidoreductase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

FlavoproteinsXanthine dehydrogenase/aldehyde oxidase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-08-21.

Open TargetsGene–disease associations from the Open Targets Platform.