Protein / target
3',5'-cyclic-AMP phosphodiesterase 4D
Protein at a glance
Biological role
3',5'-cyclic-nucleotide phosphodiesterase activity
Primary system
Cardiovascular system
Strongest disease association
acrodysostosis 2 with or without hormone resistance
Therapeutic maturity
Clinically validated target
Druggability
Small molecule
Clinical development
15 approved · 14 in clinical development
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Subcellular location
Domains and Gene Ontology detail (40)Hide
Domains & features
Gene Ontology
- Capical plasma membrane
- Ccalcium channel complex
- Ccentrosome
- Ccytosol
- Cmembrane
- Cplasma membrane
- Cvoltage-gated calcium channel complex
- F3',5'-cyclic-AMP phosphodiesterase activity
- F3',5'-cyclic-GMP phosphodiesterase activity
- F3',5'-cyclic-nucleotide phosphodiesterase activity
- FATPase binding
- Fbeta-2 adrenergic receptor binding
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
Immune signalling
- ·positive regulation of interleukin-2 production
- ·positive regulation of interleukin-5 production
- ·T cell receptor signaling pathway
Ion channel gating
- ·regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
G protein-coupled signalling
- ·negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling…
View underlying pathways (3)Hide underlying pathways
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Interaction neighbourhood
Proteins with the strongest functional or physical association. Node size and line weight reflect STRING confidence; hover or select a partner to inspect one association.
Functional and physical associations from STRING v12.0. Only associations with this protein are drawn — partner-to-partner links are not part of this evidence.
Drugs targeting this protein
Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.
Phosphodiesterase 4 inhibitor
Appears in clinical studies involving Airway obstruction, oral mucositis, Obesity, metabolic dysfunction-associated steatotic liver disease
ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.
Translational evidence
Why this target matters therapeutically — disease associations, drugs in development, tractability and safety, from Open Targets.
Strongest genetic associations
Human genetic evidence — the most direct causal link between this target and a disease.
Highest-confidence therapeutic associations
Diseases where a drug acting on this target has already reached clinical development.
Highest overall evidence
Remaining associations by Open Targets' aggregated evidence score.
Show all associationsHide all associations
Open Targets ranks 524 associations for this target and we store the top 10 by aggregated score. The long tail is largely literature co-mention and RNA-expression evidence, not evidence that this target drives those diseases.
Known drugs · 29 total
bronchitis · chronic obstructive pulmonary disease · pulmonary emphysema
asthma · asthma · chronic obstructive pulmonary disease
dysuria · Urinary incontinence · Polyuria
chronic bronchitis · psoriasis · asthma
Cough · Airway obstruction
psoriasis vulgaris · chronic obstructive pulmonary disease · rheumatoid arthritis
atopic eczema
chronic obstructive pulmonary disease · allergic rhinitis · asthma
Cognitive impairment · asthma · seasonal allergic rhinitis
Castleman disease · Airway obstruction · amyotrophic lateral sclerosis
Tractability
Safety liabilities
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.
ClinicalTrials.gov via the drug-target graph.
Forefront confidence
Our own weighting of the evidence behind each disease association. Human genetics and clinical evidence count for most; literature co-mention counts for little, because two entities sharing an abstract is not evidence that one drives the other.
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the underlying per-type scores are shown above so the calculation can be checked.
What's happening now
Recent activity around this target, drawn from one canonical event stream. Every item is reached through a drug that targets this protein, so each event is news about that drug rather than about the protein directly.
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.