Protein / target

Apolipoprotein E

APOEP02649
UniProt: P02649
19
Research papers

Protein at a glance

Research activity

Emerging research

19 papers · latest 2024

Derived from structured UniProt, Open Targets and literature data on this page.

Research activity

19 papers · to 2024

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Oxidative damage is the earliest event in Alzheimer disease.1,298 cites

Nunomura A · Journal of neuropathology and experimental neurology · 2001

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.1,252 cites

Kersten S · The Journal of clinical investigation · 1999

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.955 cites

Ossenkoppele R · Brain : a journal of neurology · 2016

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.675 cites

Guo T · Molecular neurodegeneration · 2020

American Medical Society for Sports Medicine position statement: concussion in sport.650 cites

Harmon KG · British journal of sports medicine · 2013

Recent

ApoE: The Non-Protagonist Actor in Neurological Diseases.

Grimaldi L · Genes · 2024

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease.

Wang L · Molecular neurodegeneration · 2024

APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling.

Ning Z · Cellular & molecular biology letters · 2024

Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.

Jin S · Nature communications · 2023

ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease.

Ramsden CE · Acta neuropathologica communications · 2023

MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum.

Lew CO · Radiology · 2023

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus.

Lee JY · Molecular neurodegeneration · 2023

The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.

Nelson MR · Nature neuroscience · 2023

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.

Watanabe H · Stem cell reports · 2023

ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.

Raulin AC · Molecular neurodegeneration · 2022

Europe PMC papers linked directly to this protein.