Back to discover

Protein / target

C-C motif chemokine 8

Encoded byCCL8P80075Homo sapiensSwiss-Prot
UniProt: P80075Ensembl: ENSG00000108700HGNC: HGNC:10635NCBI Gene: 6355
Antibody-tractable
Druggability
UniProt loc med conf
1
Research papers

Protein at a glance

Biological role

Phospholipase activator

Strongest disease association

Alcohol drinking

Via encoding gene CCL8 · Genetic evidence · score 0.20

Research activity

Emerging research

1 papers · latest 2019

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils.

View complete UniProt function annotation

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8

Subcellular location

Secreted
Domains and Gene Ontology detail (21)

Gene Ontology

  • Cextracellular space
  • FCCR chemokine receptor binding
  • Fchemokine activity
  • Fheparin binding
  • Fphospholipase activator activity
  • Fprotein kinase activity
  • Pantimicrobial humoral immune response mediated by antimicrobial peptide
  • Pcalcium ion transport
  • Pcell-cell signaling
  • Pchemokine-mediated signaling pathway
  • Pchemotaxis
  • Peosinophil chemotaxis

99 aa · 11 kDa

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Cell migrationGOImmune signallingGO
View supporting evidence

Cell migration

  • ·chemotaxis
  • ·eosinophil chemotaxis
  • ·positive regulation of cell migration

Immune signalling

  • ·antimicrobial humoral immune response mediated by antimicrobial peptide
  • ·inflammatory response

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene CCL8

Gene-level evidence surfaced through the gene CCL8 that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Alcohol drinking
0.20Preliminary

Genetic evidence dominant · Open Targets 0.12

Inflammatory Bowel Diseases
0.16Preliminary

Genetic evidence dominant · Open Targets 0.09

Lupus Erythematosus, Systemic
0.15Preliminary

Literature evidence dominant · Open Targets 0.09

Neoplasms
0.14Preliminary

Literature evidence dominant · Open Targets 0.11 · no direct causal or clinical evidence

Idiopathic Pulmonary Fibrosis
0.12Preliminary

Literature evidence dominant · Open Targets 0.10 · no direct causal or clinical evidence

View evidence synthesis (5)
Alcohol drinkingPreliminary
0.20
agreement 0.08–0.32
Genetic100%

Open Targets aggregate 0.12 · 1 independent evidence family

Inflammatory Bowel DiseasesPreliminary
0.16
agreement 0.02–0.30
Genetic83%Literature17%

Open Targets aggregate 0.09 · 2 independent evidence families

Lupus Erythematosus, SystemicPreliminary
0.15
agreement 0.03–0.28
Literature65%Genetic26%RNA expression9%

Open Targets aggregate 0.09 · 3 independent evidence families

NeoplasmsPreliminary
0.14
agreement 0.00–0.41
Literature100%

Open Targets aggregate 0.11 · 1 independent evidence family · no direct causal or clinical evidence

Idiopathic Pulmonary FibrosisPreliminary
0.12
agreement 0.00–0.39
Literature100%

Open Targets aggregate 0.10 · 1 independent evidence family · no direct causal or clinical evidence

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Neurodegenerative Diseases0.15
Alcohol drinking0.12
Neoplasms0.11
Idiopathic Pulmonary Fibrosis0.10
Lupus Erythematosus, Systemic0.09
Inflammatory Bowel Diseases0.09
Tuberculosis0.08

Tractability

Antibodies — Emerging

Feasibility evidence (uniprot loc med conf and uniprot sigp or tmhmm) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (3)
AB · UniProt loc med confAB · UniProt SigP or TMHMMAB · GO CC med conf

Raw Open Targets tractability assessment buckets, by modality.

Research activity

1 papers · to 2019

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.782 cites

Cassetta L · Cancer cell · 2019

Recent

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.

Cassetta L · Cancer cell · 2019

Europe PMC papers linked directly to this protein.