Protein / target

Carbapenem-hydrolyzing beta-lactamase KPC-2

KPC-2Q9F663Klebsiella pneumoniaeSwiss-Prot
UniProt: Q9F663
1
Drugs targeting

Protein at a glance

Biological role

Beta-lactamase activity

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function

Class A beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, cephalosporins and carbapenems (PubMed:11257029). Acts via hydrolysis of the beta-lactam ring (PubMed:11257029, PubMed:33257320). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities (PubMed:11257029, PubMed:33257320)

Domains and Gene Ontology detail (4)

Gene Ontology

  • Ccytosol
  • Fbeta-lactamase activity
  • Pbeta-lactam antibiotic catabolic process
  • Presponse to antibiotic

293 aa · 31 kDa

Biological roles

Reactome v97

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

View underlying pathways (1)
Antimicrobial resistance

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Drugs targeting this protein

1

Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.

vaborbactam
Narrow target profileInhibitor

Carbepenem-hydrolyzing beta-lactamase KPC inhibitor

Direct interaction with this protein · Only this protein recorded as a target

ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.

What's happening now

1

Recent activity around this target, drawn from one canonical event stream. Every item is reached through a drug that targets this protein, so each event is news about that drug rather than about the protein directly.

  1. New publication2021-05-02
    New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.

    Molecules (Basel, Switzerland) · 2021 · 302 citations · Europe PMC · via vaborbactam

Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.