Protein / target
cGMP-specific 3',5'-cyclic phosphodiesterase
Protein at a glance
Biological role
3',5'-cyclic-nucleotide phosphodiesterase
Strongest disease association
Coronary Artery Disease
Therapeutic position
Established drug target
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides.
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Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334)
Domains and Gene Ontology detail (12)Hide
Domains & features
Gene Ontology
- Ccytosol
- F3',5'-cyclic-AMP phosphodiesterase activity
- F3',5'-cyclic-GMP phosphodiesterase activity
- F3',5'-cyclic-nucleotide phosphodiesterase activity
- FcGMP binding
- Fmetal ion binding
- PcGMP catabolic process
- Pnegative regulation of cAMP/PKA signal transduction
- Psignal transduction
Approved medicines with mapped indications
Approved therapies targeting this protein, grouped by what they are approved to treat — the disease-first view of the medicines below. Relationships come from the canonical approved-indication graph (ChEMBL phase-4), the same source as the drug cards.
10 medicines meet Open Targets' target-level approved-medicine definition; the 2 shown here are those on this page with a canonical approved disease indication in the graph. Approved indications from ChEMBL (phase-4), via the canonical drug→disease graph.
Drugs targeting this protein
How approved and investigational drugs engage this protein — mechanism and action type, direct vs complex targeting, and how broadly each acts across other targets. A drug-first view (the section above groups the approved ones disease-first); direct binders with few recorded targets are listed first.
Phosphodiesterase 5A inhibitor
Indicated for Erectile Dysfunction, Hypertension, Pulmonary
Phosphodiesterase 5A inhibitor
Indicated for Erectile Dysfunction
ChEMBL mechanism, action type, target identity and approved indications. Open Targets clinical status.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene PDE5A
Gene-level evidence surfaced through the gene PDE5Athat encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
View evidence synthesis (5)Hide
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Drug development
13 compounds recorded · 10 approved · 3 in clinical development
View all recorded compounds (10)Hide
Open Targets known-drugs universe. Drug name and highest clinical stage only — the disease relationship is NOT read from this slice (it carries trial-context noise); approved indications come from the canonical graph above.
Tractability
Small molecules — Strong
Protein degraders — Emerging
View underlying tractability evidence (7)Hide
Raw Open Targets tractability assessment buckets, by modality.
Safety-related annotations
Terms indexed against this target in Open Targets' safety data, with their datasource. These are annotations, not causal claims: the direction of effect (whether activation or inhibition is implicated), species and evidence strength are not captured here, so an entry does not mean that modulating this target is known to cause that condition.
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein. Ranked by active status, then clinical phase and recency, and spread across the targeting drugs.
View all trials (26)Hide
ClinicalTrials.gov via the drug-target graph.
What's happening now
Recent therapeutic activity around this target — regulatory actions, clinical trials and safety signals for 2 drugs that target this protein, plus publications where such a drug is a genuine subject. Every item is reached indirectly through the drug, not the protein itself; incidental mentions (a paper that merely measures a drug) and press items are excluded.
- Regulatory approval
Approval: TADALAFIL (ANDA210592)
- Regulatory approval
Approval: TADALAFIL (ANDA217606)
- Regulatory approval
Approval: Tadalafil Lilly (EMA)
- Regulatory approval
Approval: Talmanco (previously Tadalafil Generics) (EMA)
- New publicationTadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma.
- Regulatory approval
Approval: Tadalafil Mylan (EMA)
- New publicationTadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma.
- Regulatory approval
Approval: Spedra (EMA)
- New publicationEffects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors.
- New publicationA randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction.
- Regulatory approval
Approval: Adcirca (previously Tadalafil Lilly) (EMA)
- Regulatory approval
Approval: Cialis (EMA)
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.