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Protein / target

Cocaine- and amphetamine-regulated transcript protein

Encoded byCARTPTQ16568Homo sapiensSwiss-Prot
UniProt: Q16568Ensembl: ENSG00000164326HGNC: HGNC:24323NCBI Gene: 9607
Antibody-tractable
Druggability
UniProt loc high conf
1
Research papers

Protein at a glance

Biological role

Neuropeptide hormone

Strongest disease association

Gastrointestinal Diseases

Via encoding gene CARTPT · Genetic evidence · score 0.50

Research activity

Emerging research

1 papers · latest 2014

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.

View complete UniProt function annotation

Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro

Subcellular location

Secreted
Domains and Gene Ontology detail (57)

Gene Ontology

  • Cextracellular space
  • Cneuronal cell body
  • Csecretory granule
  • Csynapse
  • Fneuropeptide hormone activity
  • Padult feeding behavior
  • Pbehavioral response to cocaine
  • PcAMP biosynthetic process
  • Pcell-cell signaling
  • Pcellular response to estradiol stimulus
  • Pcellular response to starvation
  • Pchemical synaptic transmission

116 aa · 13 kDa

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Synaptic signallingGOMotor controlGO
View supporting evidence

Synaptic signalling

  • ·synapse
  • ·chemical synaptic transmission

Motor control

  • ·negative regulation of locomotion
  • ·regulation of locomotion involved in locomotory behavior

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene CARTPT

Gene-level evidence surfaced through the gene CARTPTthat encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Gastrointestinal Diseases
0.50Moderately supported

Genetic evidence dominant · Open Targets 0.30

Obesity disorder
0.39Limited support

Genetic evidence dominant · Open Targets 0.16

Empyema, Pleural
0.32Limited support

Genetic evidence dominant · Open Targets 0.20

Amblyopia
0.24Preliminary

Genetic evidence dominant · Open Targets 0.15

Arthritis, Psoriatic
0.22Preliminary

Genetic evidence dominant · Open Targets 0.13

View evidence synthesis (5)
Gastrointestinal DiseasesModerately supported
0.50
agreement 0.38–0.62
Genetic100%

Open Targets aggregate 0.30 · 1 independent evidence family

Obesity disorderLimited support
0.39
agreement 0.27–0.51
Genetic52%Animal model35%Literature13%

Open Targets aggregate 0.16 · 3 independent evidence families

Empyema, PleuralLimited support
0.32
agreement 0.20–0.44
Genetic100%

Open Targets aggregate 0.20 · 1 independent evidence family

AmblyopiaPreliminary
0.24
agreement 0.12–0.36
Genetic100%

Open Targets aggregate 0.15 · 1 independent evidence family

Arthritis, PsoriaticPreliminary
0.22
agreement 0.10–0.34
Genetic100%

Open Targets aggregate 0.13 · 1 independent evidence family

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Gastrointestinal Diseases0.30
Empyema, Pleural0.20
Obesity disorder0.16
Amblyopia0.15
Arthritis, Psoriatic0.13
Von Willebrand disease0.13
Neoplasms0.09

Tractability

Antibodies — Emerging

Feasibility evidence (uniprot loc high conf and uniprot sigp or tmhmm) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (3)
AB · UniProt loc high confAB · UniProt SigP or TMHMMAB · GO CC med conf

Raw Open Targets tractability assessment buckets, by modality.

Research activity

1 papers · to 2014

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.698 cites

Secher A · The Journal of clinical investigation · 2014

Recent

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.

Secher A · The Journal of clinical investigation · 2014

Europe PMC papers linked directly to this protein.