Protein / target
C-reactive protein
Protein at a glance
Biological role
Low-density lipoprotein particle receptor binding
Strongest disease association
Pneumonia
Research activity
Actively researched
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine.
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Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells
Subcellular location
Domains and Gene Ontology detail (21)Hide
Domains & features
Gene Ontology
- Cextracellular region
- Cextracellular space
- Fcalcium ion binding
- Fcholine binding
- Fcomplement component C1q complex binding
- Fidentical protein binding
- Flow-density lipoprotein particle binding
- Flow-density lipoprotein particle receptor binding
- Pacute-phase response
- Pdefense response to Gram-positive bacterium
- Pinflammatory response
- Pinnate immune response
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Immune signalling
- ·inflammatory response
- ·innate immune response
- ·regulation of interleukin-8 production
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene CRP
Gene-level evidence surfaced through the gene CRP that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
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The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Tractability
Small molecules — Emerging
Antibodies — Emerging
View underlying tractability evidence (5)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.