Protein / target

Myelin-oligodendrocyte glycoprotein

Encoded byMOGQ16653Homo sapiensSwiss-Prot

UniProt: Q16653 Ensembl: ENSG00000137345 HGNC: HGNC:7197 NCBI Gene: 4340

Antibody-tractable

Druggability

UniProt loc high conf

Research papers

Protein at a glance

Biological role

Signaling receptor binding

Strongest disease association

Transient neonatal diabetes mellitus

Via encoding gene MOG · Genetic evidence · score 0.85

Research activity

Emerging research

4 papers · latest 2020

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Mediates homophilic cell-cell adhesion.

View complete UniProt function annotation

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

Subcellular location

Cell membrane

Domains and Gene Ontology detail (9)

Domains & features

Ig-like V-type

Gene Ontology

Cexternal side of plasma membrane
Cplasma membrane
Fsignaling receptor binding
Fvirus receptor activity
Pcell adhesion
Pcentral nervous system development
Pregulation of cytokine production
PT cell receptor signaling pathway

247 aa · 28 kDa · 13 isoforms

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Cell adhesionUniProt · GOImmune signallingGO

View supporting evidence

Cell adhesion

·Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sh…
·cell adhesion

Immune signalling

·regulation of cytokine production
·T cell receptor signaling pathway

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene MOG

Gene-level evidence surfaced through the gene MOGthat encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Transient neonatal diabetes mellitus

0.87Well supported

Genetic evidence dominant · Open Targets 0.54

Narcolepsy-cataplexy syndrome

0.60Moderately supported

Genetic evidence dominant · Open Targets 0.51

Genetic Diseases, Inborn

0.32Limited support

Genetic evidence dominant · Open Targets 0.19

Alzheimer's Disease

0.14Preliminary

Literature evidence dominant · Open Targets 0.12 · no direct causal or clinical evidence

Encephalomyelitis, Acute Disseminated

0.14Preliminary

Literature evidence dominant · Open Targets 0.11 · no direct causal or clinical evidence

View evidence synthesis (5)

Transient neonatal diabetes mellitusWell supported

0.87

agreement 0.76–0.97

Genetic87%Somatic mutation13%

Open Targets aggregate 0.54 · 2 independent evidence families

Narcolepsy-cataplexy syndromeModerately supported

0.60

agreement 0.48–0.72

Genetic100%Genetic literaturedup

Open Targets aggregate 0.51 · 1 independent evidence family · 1 not counted as duplicate

Genetic Diseases, InbornLimited support

0.32

agreement 0.20–0.44

Genetic100%

Open Targets aggregate 0.19 · 1 independent evidence family

Alzheimer's DiseasePreliminary

0.14

agreement 0.00–0.42

Literature100%

Open Targets aggregate 0.12 · 1 independent evidence family · no direct causal or clinical evidence

Encephalomyelitis, Acute DisseminatedPreliminary

0.14

agreement 0.00–0.41

Literature100%

Open Targets aggregate 0.11 · 1 independent evidence family · no direct causal or clinical evidence

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations

Transient neonatal diabetes mellitus0.54

Narcolepsy-cataplexy syndrome0.51

Genetic Diseases, Inborn0.19

Alzheimer's Disease0.12

Encephalomyelitis, Acute Disseminated0.11

Neuromyelitis Optica0.11

Optic Neuritis0.10

Tractability

Antibodies — Emerging

Feasibility evidence (uniprot loc high conf and uniprot sigp or tmhmm) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (3)