Protein / target
CD27 antigen
Protein at a glance
Biological role
Transmembrane signaling receptor
Strongest disease association
Severe Combined Immunodeficiency
Therapeutic position
Clinically advancing target
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells.
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Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells (PubMed:28011863). The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (PubMed:38354704). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (By similarity). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (By similarity)
Subcellular location
Domains and Gene Ontology detail (16)Hide
Gene Ontology
- Cexternal side of plasma membrane
- Cextracellular region
- Cplasma membrane
- Fcysteine-type endopeptidase inhibitor activity involved in apoptotic process
- Ftransmembrane signaling receptor activity
- Padaptive immune memory response involving T cells and B cells
- PCD27 signaling pathway
- Pcell surface receptor signaling pathway
- Pextrinsic apoptotic signaling pathway
- Pimmunoglobulin mediated immune response
- Pnegative regulation of apoptotic process
- Ppositive regulation of B cell differentiation
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Immune signalling
- ·Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells a…
- ·adaptive immune memory response involving T cells and B cells
- ·immunoglobulin mediated immune response
- ·positive regulation of B cell differentiation
Apoptosis & cell death
- ·cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- ·negative regulation of apoptotic process
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene CD27
Gene-level evidence surfaced through the gene CD27 that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
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The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Drug development
1 compounds recorded · 1 in clinical development
View all recorded compounds (1)Hide
Open Targets known-drugs universe. Drug name and highest clinical stage only — the disease relationship is NOT read from this slice (it carries trial-context noise); approved indications come from the canonical graph above.
Tractability
Antibodies — Strong
Protein degraders — Emerging
View underlying tractability evidence (5)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.