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Protein / target

T-box transcription factor T

Encoded byTBXTO15178Homo sapiensSwiss-Prot
UniProt: O15178Ensembl: ENSG00000164458HGNC: HGNC:11515NCBI Gene: 6862
Small-molecule tractable
Druggability
Structure with Ligand
1
Research papers

Protein at a glance

Biological role

Sequence-specific double-stranded DNA binding

Strongest disease association

Chordoma

Via encoding gene TBXT · Genetic literature evidence · score 0.61

Research activity

Emerging research

1 papers · latest 2024

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation.

View complete UniProt function annotation

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site

Subcellular location

Nucleus
Domains and Gene Ontology detail (22)

Gene Ontology

  • Cchromatin
  • Cnucleoplasm
  • Cnucleus
  • FDNA-binding transcription factor activity
  • FDNA-binding transcription factor activity, RNA polymerase II-specific
  • FRNA polymerase II cis-regulatory region sequence-specific DNA binding
  • FRNA polymerase II-specific DNA-binding transcription factor binding
  • Fsequence-specific double-stranded DNA binding
  • Ftranscription corepressor activity
  • Panterior/posterior axis specification, embryo
  • Pcardiac muscle cell myoblast differentiation
  • Pcell fate specification

435 aa · 47 kDa · 2 isoforms

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Transcriptional regulationUniProt · GO
View supporting evidence

Transcriptional regulation

  • ·Involved in the transcriptional regulation of genes required for mesoderm formation and…
  • ·DNA-binding transcription factor activity
  • ·DNA-binding transcription factor activity, RNA polymerase II-specific
  • ·RNA polymerase II cis-regulatory region sequence-specific DNA binding

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene TBXT

Gene-level evidence surfaced through the gene TBXT that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Chordoma
0.55Moderately supported

Genetic literature evidence dominant · Open Targets 0.39

Smoking initiation
0.38Limited support

Genetic evidence dominant · Open Targets 0.23

Liver Diseases
0.24Preliminary

Genetic evidence dominant · Open Targets 0.15

Respiratory Tract Infections
0.24Preliminary

Genetic evidence dominant · Open Targets 0.15

Neural Tube Defects
0.20Preliminary

Genetic evidence dominant · Open Targets 0.12

View evidence synthesis (5)
ChordomaModerately supported
0.55
agreement 0.40–0.70
Genetic literature80%Literature20%

Open Targets aggregate 0.39 · 2 independent evidence families

Smoking initiationLimited support
0.38
agreement 0.26–0.50
Genetic100%

Open Targets aggregate 0.23 · 1 independent evidence family

Liver DiseasesPreliminary
0.24
agreement 0.10–0.38
Genetic96%Literature4%

Open Targets aggregate 0.15 · 2 independent evidence families

Respiratory Tract InfectionsPreliminary
0.24
agreement 0.12–0.36
Genetic100%

Open Targets aggregate 0.15 · 1 independent evidence family

Neural Tube DefectsPreliminary
0.20
agreement 0.07–0.32
Genetic100%

Open Targets aggregate 0.12 · 1 independent evidence family

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Chordoma0.39
Smoking initiation0.23
Respiratory Tract Infections0.15
Liver Diseases0.15
Neural Tube Defects0.12
Diabetes Mellitus, Type 10.08

Tractability

Small molecules — Emerging

Feasibility evidence (structure with ligand) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (1)
SM · Structure with Ligand

Raw Open Targets tractability assessment buckets, by modality.

Research activity

1 papers · to 2024

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Chordoma: Genetics and Contemporary Management.15 cites

Desai R · International journal of molecular sciences · 2024

Recent

Chordoma: Genetics and Contemporary Management.

Desai R · International journal of molecular sciences · 2024

Europe PMC papers linked directly to this protein.