Protein / target
Mucin-5B
Protein at a glance
Biological role
Extracellular matrix structural constituent
Strongest disease association
Lung Diseases, Interstitial
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus
Subcellular location
Domains and Gene Ontology detail (19)Hide
Domains & features
Gene Ontology
- Cextracellular exosome
- Cextracellular matrix
- Cextracellular space
- CGolgi lumen
- Cplasma membrane
- Fextracellular matrix structural constituent
- Fmetal ion binding
- Pnegative regulation of single-species biofilm formation in or on host organism
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
Cell adhesion
- ·extracellular matrix
- ·extracellular matrix structural constituent
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene MUC5B
Gene-level evidence surfaced through the gene MUC5Bthat encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
View evidence synthesis (5)Hide
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Tractability
Antibodies — Emerging
View underlying tractability evidence (3)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.
Related family literature
Papers about “Mucins” — a broader family this protein belongs to. Shown as context; not counted as papers specifically about this protein.
via Mucins
via Mucins
Europe PMC literature, reached through curated HGNC family membership. Membership is a taxonomic relationship — it does not imply this protein participates in every mechanism these papers discuss.