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Protein / target

60 kDa heat shock protein, mitochondrial

Encoded byHSPD1P10809Homo sapiensSwiss-Prot
UniProt: P10809Ensembl: ENSG00000144381HGNC: HGNC:5261NCBI Gene: 3329
Small-molecule tractable
Druggability
Structure with Ligand
1
Research papers

Protein at a glance

Biological role

Cysteine-type endopeptidase activator

Strongest disease association

Atrial Fibrillation

Via encoding gene HSPD1 · Genetic evidence · score 0.45

Research activity

Emerging research

1 papers · latest 2000

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Chaperonin implicated in mitochondrial protein import and macromolecular assembly.

View complete UniProt function annotation

Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable)

Subcellular location

Mitochondrion matrix
Domains and Gene Ontology detail (64)

Gene Ontology

  • Ccell surface
  • Cclathrin-coated pit
  • Ccoated vesicle
  • Ccytoplasm
  • Ccytosol
  • Cearly endosome
  • Cextracellular exosome
  • Cextracellular space
  • Clipopolysaccharide receptor complex
  • Cmembrane
  • Cmigrasome
  • Cmitochondrial inner membrane

573 aa · 61 kDa · 2 isoforms

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Immune signallingGO
View supporting evidence

Immune signalling

  • ·B cell activation
  • ·B cell proliferation
  • ·positive regulation of interleukin-10 production
  • ·positive regulation of interleukin-12 production

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene HSPD1

Gene-level evidence surfaced through the gene HSPD1 that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Atrial Fibrillation
0.49Limited support

Genetic evidence dominant · Open Targets 0.29

Neurodegenerative Diseases
0.37Preliminary

Pathway evidence dominant · Open Targets 0.56 · no direct causal or clinical evidence

Spastic Paraplegia, Hereditary
0.33Limited support

Genetic evidence dominant · Open Targets 0.20

View evidence synthesis (3)
Atrial FibrillationLimited support
0.49
agreement 0.35–0.63
Genetic86%Literature14%

Open Targets aggregate 0.29 · 2 independent evidence families

Neurodegenerative DiseasesPreliminary
0.37
agreement 0.20–0.55
Pathway97%Literature3%

Open Targets aggregate 0.56 · 2 independent evidence families · no direct causal or clinical evidence

Spastic Paraplegia, HereditaryLimited support
0.33
agreement 0.20–0.47
Genetic93%Literature8%

Open Targets aggregate 0.20 · 2 independent evidence families

This ranking differs from Open Targets' own: re-weighting moves genetically-evidenced diseases above more heavily co-mentioned ones. The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Neurodegenerative Diseases0.56
Atrial Fibrillation0.29
Spastic Paraplegia, Hereditary0.20

Tractability

Small molecules — Emerging

Feasibility evidence (structure with ligand and high-quality ligand) — no clinical-stage drug of this modality recorded.

Antibodies — Emerging

Feasibility evidence (go cc high conf) — no clinical-stage drug of this modality recorded.

Protein degraders — Emerging

Feasibility evidence (uniprot ubiquitination and database ubiquitination) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (7)
SM · Structure with LigandSM · High-Quality LigandAB · GO CC high confPR · UniProt UbiquitinationPR · Database UbiquitinationPR · Half-life DataPR · Small Molecule Binder

Raw Open Targets tractability assessment buckets, by modality.

Research activity

1 papers · to 2000

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.1,037 cites

Ohashi K · Journal of immunology (Baltimore, Md. : 1950) · 2000

Recent

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.

Ohashi K · Journal of immunology (Baltimore, Md. : 1950) · 2000

Europe PMC papers linked directly to this protein.