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Protein / target

Transcription factor 7

Encoded byTCF7P36402Homo sapiensSwiss-Prot
UniProt: P36402Ensembl: ENSG00000081059HGNC: HGNC:11639NCBI Gene: 6932
Degrader-tractable
Druggability
Database Ubiquitination
1
Research papers

Protein at a glance

Biological role

Sequence-specific double-stranded DNA binding

Strongest disease association

Hypothyroidism

Via encoding gene TCF7 · Genetic evidence · score 0.71

Research activity

Emerging research

1 papers · latest 2024

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Transcriptional activator involved in T-cell lymphocyte differentiation.

View complete UniProt function annotation

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes

Subcellular location

Nucleus
Domains and Gene Ontology detail (18)

Gene Ontology

  • Cbeta-catenin-TCF complex
  • Cchromatin
  • Cnucleoplasm
  • Cnucleus
  • Fbeta-catenin binding
  • FDNA-binding transcription factor activity, RNA polymerase II-specific
  • FDNA-binding transcription repressor activity
  • FRNA polymerase II cis-regulatory region sequence-specific DNA binding
  • Fsequence-specific double-stranded DNA binding
  • Ftranscription cis-regulatory region binding
  • Pcanonical Wnt signaling pathway
  • Pcellular response to interleukin-4

384 aa · 42 kDa · 15 isoforms

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Transcriptional regulationUniProt · GOImmune signallingGO
View supporting evidence

Transcriptional regulation

  • ·Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for t…
  • ·DNA-binding transcription factor activity, RNA polymerase II-specific
  • ·DNA-binding transcription repressor activity
  • ·RNA polymerase II cis-regulatory region sequence-specific DNA binding

Immune signalling

  • ·cellular response to interleukin-4
  • ·gamma-delta T cell differentiation
  • ·immune response
  • ·regulation of gamma-delta T cell differentiation

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene TCF7

Gene-level evidence surfaced through the gene TCF7that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Hypothyroidism
0.71Moderately supported

Genetic evidence dominant · Open Targets 0.43

Asthma
0.71Moderately supported

Genetic evidence dominant · Open Targets 0.43

Lupus Erythematosus, Systemic
0.69Moderately supported

Genetic evidence dominant · Open Targets 0.42

Arthritis, Rheumatoid
0.56Moderately supported

Genetic evidence dominant · Open Targets 0.34

Alcohol drinking
0.55Moderately supported

Genetic evidence dominant · Open Targets 0.33

View evidence synthesis (5)
HypothyroidismModerately supported
0.71
agreement 0.59–0.83
Genetic100%

Open Targets aggregate 0.43 · 1 independent evidence family

AsthmaModerately supported
0.71
agreement 0.57–0.85
Genetic93%Literature7%

Open Targets aggregate 0.43 · 2 independent evidence families

Lupus Erythematosus, SystemicModerately supported
0.69
agreement 0.55–0.83
Genetic95%Literature5%

Open Targets aggregate 0.42 · 2 independent evidence families

Arthritis, RheumatoidModerately supported
0.56
agreement 0.42–0.70
Genetic96%Literature4%

Open Targets aggregate 0.34 · 2 independent evidence families

Alcohol drinkingModerately supported
0.55
agreement 0.43–0.67
Genetic100%

Open Targets aggregate 0.33 · 1 independent evidence family

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Neurodegenerative Diseases0.44
Hypothyroidism0.43
Asthma0.43
Lupus Erythematosus, Systemic0.42
Arthritis, Rheumatoid0.34
Alcohol drinking0.33
Chronic rhinosinusitis0.33
Hashimoto's Disease0.33
Graves' Disease0.33
Thyroiditis, Autoimmune0.32

Tractability

Protein degraders — Emerging

Feasibility evidence (database ubiquitination and small molecule binder) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (2)
PR · Database UbiquitinationPR · Small Molecule Binder

Raw Open Targets tractability assessment buckets, by modality.

Safety-related annotations

regulation of transcription factor activityToxCast

Terms indexed against this target in Open Targets' safety data, with their datasource. These are annotations, not causal claims: the direction of effect (whether activation or inhibition is implicated), species and evidence strength are not captured here, so an entry does not mean that modulating this target is known to cause that condition.

Research activity

1 papers · to 2024

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

FOXO1 is a master regulator of memory programming in CAR T cells.154 cites

Doan AE · Nature · 2024

Recent

FOXO1 is a master regulator of memory programming in CAR T cells.

Doan AE · Nature · 2024

Europe PMC papers linked directly to this protein.