Protein / target
Elastin
Protein at a glance
Biological role
Extracellular matrix constituent conferring elasticity
Strongest disease association
Genetic Diseases, Inborn
Therapeutic position
Clinically advancing target
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.
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Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity)
Subcellular location
Domains and Gene Ontology detail (13)Hide
Gene Ontology
- Celastic fiber
- Cextracellular matrix
- Cextracellular region
- Fextracellular matrix binding
- Fextracellular matrix constituent conferring elasticity
- Fextracellular matrix structural constituent
- Panimal organ morphogenesis
- Paortic valve morphogenesis
- Pblood circulation
- Pextracellular matrix assembly
- Poutflow tract morphogenesis
- Pregulation of smooth muscle cell proliferation
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Cell adhesion
- ·Secreted, extracellular space, extracellular matrix
- ·extracellular matrix
- ·extracellular matrix binding
- ·extracellular matrix constituent conferring elasticity
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene ELN
Gene-level evidence surfaced through the gene ELN that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
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The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Drug development
1 compounds recorded · 1 in clinical development
View all recorded compounds (1)Hide
Open Targets known-drugs universe. Drug name and highest clinical stage only — the disease relationship is NOT read from this slice (it carries trial-context noise); approved indications come from the canonical graph above.
Tractability
Antibodies — Emerging
Other modalities — Strong
View underlying tractability evidence (5)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.