Protein / target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Protein at a glance
Biological role
Enoyl-[acyl-carrier-protein] reductase (NADH) activity
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function
Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis
Domains and Gene Ontology detail (12)Hide
Gene Ontology
- Ccatalytic complex
- Ccytosol
- Cmembrane
- Cprotein-containing complex
- Fenoyl-[acyl-carrier-protein] reductase (NADH) activity
- Fidentical protein binding
- FNADH binding
- Pbiotin biosynthetic process
- Pfatty acid elongation
- Plipid biosynthetic process
- Pprotein homotetramerization
- Presponse to antibiotic
Drugs targeting this protein
Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.
Bacterial enoyl-[acyl-carrier-protein] reductase inhibitor
ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.
ClinicalTrials.gov via the drug-target graph.
What's happening now
Recent activity around this target, drawn from one canonical event stream. Every item is reached through a drug that targets this protein, so each event is news about that drug rather than about the protein directly.
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.