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Protein / target

Erythroid transcription factor

Encoded byGATA1P15976Homo sapiensSwiss-Prot
UniProt: P15976Ensembl: ENSG00000102145HGNC: HGNC:4170NCBI Gene: 2623
Degrader-tractable
Druggability
UniProt Ubiquitination
1
Research papers

Protein at a glance

Biological role

Sequence-specific double-stranded DNA binding

Research activity

Emerging research

1 papers · latest 2020

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Transcriptional activator or repressor which serves as a general switch factor for erythroid development.

View complete UniProt function annotation

Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781)

Subcellular location

Nucleus
Domains and Gene Ontology detail (48)

Gene Ontology

  • Cchromatin
  • Cnucleoplasm
  • Cnucleus
  • Cprotein-DNA complex
  • Ctranscription regulator complex
  • Ctranscription repressor complex
  • FC2H2 zinc finger domain binding
  • Fchromatin DNA binding
  • FDNA binding
  • FDNA-binding transcription activator activity, RNA polymerase II-specific
  • FDNA-binding transcription factor activity
  • FDNA-binding transcription factor activity, RNA polymerase II-specific

413 aa · 43 kDa · 3 isoforms

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Transcriptional regulationUniProt · GOHaemostasisGO
View supporting evidence

Transcriptional regulation

  • ·Transcriptional activator or repressor which serves as a general switch factor for eryth…
  • ·transcription regulator complex
  • ·transcription repressor complex
  • ·DNA-binding transcription activator activity, RNA polymerase II-specific

Haemostasis

  • ·platelet aggregation
  • ·platelet formation

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Tractability

Protein degraders — Emerging

Feasibility evidence (uniprot ubiquitination) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (1)
PR · UniProt Ubiquitination

Raw Open Targets tractability assessment buckets, by modality.

Safety-related annotations

regulation of transcription factor activityToxCast

Terms indexed against this target in Open Targets' safety data, with their datasource. These are annotations, not causal claims: the direction of effect (whether activation or inhibition is implicated), species and evidence strength are not captured here, so an entry does not mean that modulating this target is known to cause that condition.

Research activity

1 papers · to 2020

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Whole-genome sequencing of patients with rare diseases in a national health system.437 cites

Turro E · Nature · 2020

Recent

Whole-genome sequencing of patients with rare diseases in a national health system.

Turro E · Nature · 2020

Europe PMC papers linked directly to this protein.