Protein / target
Follicle-stimulating hormone receptor
Protein at a glance
Biological role
Follicle-stimulating hormone receptor activity
Strongest disease association
ovarian hyperstimulation syndrome
Therapeutic maturity
Clinically validated target
Druggability
Small molecule
Clinical development
7 approved
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690)
Subcellular location
Domains and Gene Ontology detail (22)Hide
Domains & features
Gene Ontology
- Ccell surface
- Cendosome
- Cmembrane
- Cplasma membrane
- Creceptor complex
- Ffollicle-stimulating hormone receptor activity
- FG protein-coupled peptide receptor activity
- Fpeptide hormone binding
- Padenylate cyclase-activating G protein-coupled receptor signaling pathway
- Pcellular response to follicle-stimulating hormone stimulus
- Pfemale gamete generation
- Pfemale gonad development
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
G protein-coupled signalling
- ·G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:118…
- ·G protein-coupled peptide receptor activity
- ·adenylate cyclase-activating G protein-coupled receptor signaling pathway
- ·G protein-coupled receptor signaling pathway
Kinase signalling
- ·positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
View underlying pathways (2)Hide underlying pathways
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Interaction neighbourhood
Proteins with the strongest functional or physical association. Node size and line weight reflect STRING confidence; hover or select a partner to inspect one association.
Functional and physical associations from STRING v12.0. Only associations with this protein are drawn — partner-to-partner links are not part of this evidence.
Drugs targeting this protein
Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.
Follicle stimulating hormone receptor agonist
ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.
Translational evidence
Why this target matters therapeutically — disease associations, drugs in development, tractability and safety, from Open Targets.
Strongest genetic associations
Human genetic evidence — the most direct causal link between this target and a disease.
Highest-confidence therapeutic associations
Diseases where a drug acting on this target has already reached clinical development.
Highest overall evidence
Remaining associations by Open Targets' aggregated evidence score.
Show all associationsHide all associations
Open Targets ranks 1,401 associations for this target and we store the top 10 by aggregated score. The long tail is largely literature co-mention and RNA-expression evidence, not evidence that this target drives those diseases.
Known drugs · 7 total
female infertility · infertility disorder · polycystic ovary syndrome
female infertility · hypogonadotropic hypogonadism · Infertility
anovulation · hypogonadism · female infertility
anovulation · female infertility · infertility disorder
primary ovarian failure · hypogonadotropic hypogonadism · hypogonadism
Infertility · positive regulation of ovulation · ovarian hyperstimulation syndrome
anovulation · infertility disorder · Infertility
Tractability
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.
Show remaining trials (10)Hide
ClinicalTrials.gov via the drug-target graph.
Forefront confidence
Our own weighting of the evidence behind each disease association. Human genetics and clinical evidence count for most; literature co-mention counts for little, because two entities sharing an abstract is not evidence that one drives the other.
This ranking differs from Open Targets' own: re-weighting moves genetically-evidenced diseases above more heavily co-mentioned ones. The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the underlying per-type scores are shown above so the calculation can be checked.
What's happening now
Recent activity around this target, drawn from one canonical event stream. Every item is reached through a drug that targets this protein, so each event is news about that drug rather than about the protein directly.
- New publicationMuscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis.
- New publicationThe satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion.
- New publicationClustering Identifies Subtypes With Different Phenotypic Characteristics in Women With Polycystic Ovary Syndrome.
- New publicationFollicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation.
- New publicationHormone Regulation in Testicular Development and Function.
- New publicationDisturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation.
- New publicationThe value of luteinizing hormone basal values and sex hormone-binding globulin for early diagnosis of rapidly progressive central precocious puberty.
- New publicationMetabolic characteristics of obese patients with polycystic ovarian syndrome: a meta-analysis.
- New publicationGonadotropin-Releasing Hormone Receptor (GnRHR) and Hypogonadotropic Hypogonadism.
- New publicationFollicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets.
- New publicationInfluence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome.
- Regulatory approval
Approval: Rekovelle (EMA)
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.