Protein / target
Glial fibrillary acidic protein
Protein at a glance
Biological role
Structural constituent of cytoskeleton
Strongest disease association
Genetic Diseases, Inborn
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells
Subcellular location
Domains and Gene Ontology detail (20)Hide
Domains & features
Gene Ontology
- Castrocyte end-foot
- Ccell body
- Ccell projection
- Ccytoplasm
- Ccytoplasmic side of lysosomal membrane
- Ccytosol
- Cintermediate filament
- Cintermediate filament cytoskeleton
- Fidentical protein binding
- Fintegrin binding
- Fkinase binding
- Fstructural constituent of cytoskeleton
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
Cell migration
- ·neural crest cell migration
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene GFAP
Gene-level evidence surfaced through the gene GFAP that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
View evidence synthesis (3)Hide
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
Show all associationsHide all associations
Tractability
Protein degraders — Emerging
View underlying tractability evidence (1)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.