Protein / target
Glutamate carboxypeptidase 2
Protein at a glance
Biological role
Tetrahydrofolyl-poly(glutamate) polymer binding
Strongest disease association
Venous Thromboembolism
Therapeutic position
Established drug target
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.
View complete UniProt function annotationHide complete annotation
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression
Subcellular location
Domains and Gene Ontology detail (16)Hide
Gene Ontology
- Ccell surface
- Ccytoplasm
- Cextracellular exosome
- Cmembrane
- Cplasma membrane
- FAc-Asp-Glu binding
- Fcarboxypeptidase activity
- Fdipeptidase activity
- Fmetal ion binding
- Fmetallocarboxypeptidase activity
- Fpeptidase activity
- Ftetrahydrofolyl-poly(glutamate) polymer binding
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Proteolysis
- ·carboxypeptidase activity
- ·dipeptidase activity
- ·metallocarboxypeptidase activity
- ·peptidase activity
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Approved medicines with mapped indications
Approved therapies targeting this protein, grouped by what they are approved to treat — the disease-first view of the medicines below. Relationships come from the canonical approved-indication graph (ChEMBL phase-4), the same source as the drug cards.
Approved indications from ChEMBL (phase-4), via the canonical drug→disease graph.
Drugs targeting this protein
How approved and investigational drugs engage this protein — mechanism and action type, direct vs complex targeting, and how broadly each acts across other targets. A drug-first view (the section above groups the approved ones disease-first); direct binders with few recorded targets are listed first.
Glutamate carboxypeptidase II binding agent
Indicated for Prostatic Neoplasms, Castration-Resistant
ChEMBL mechanism, action type, target identity and approved indications. Open Targets clinical status.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene FOLH1
Gene-level evidence surfaced through the gene FOLH1 that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
View evidence synthesis (5)Hide
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Drug development
6 compounds recorded · 1 approved · 5 in clinical development
View all recorded compounds (6)Hide
Open Targets known-drugs universe. Drug name and highest clinical stage only — the disease relationship is NOT read from this slice (it carries trial-context noise); approved indications come from the canonical graph above.
Tractability
Small molecules — Strong
Antibodies — Strong
Protein degraders — Emerging
Other modalities — Strong
View underlying tractability evidence (11)Hide
Raw Open Targets tractability assessment buckets, by modality.
Safety-related annotations
Terms indexed against this target in Open Targets' safety data, with their datasource. These are annotations, not causal claims: the direction of effect (whether activation or inhibition is implicated), species and evidence strength are not captured here, so an entry does not mean that modulating this target is known to cause that condition.
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein. Ranked by active status, then clinical phase and recency, and spread across the targeting drugs.
View all trials (26)Hide
ClinicalTrials.gov via the drug-target graph.
What's happening now
Recent therapeutic activity around this target — regulatory actions, clinical trials and safety signals for a drug that targets this protein, plus publications where such a drug is a genuine subject. Every item is reached indirectly through the drug, not the protein itself; incidental mentions (a paper that merely measures a drug) and press items are excluded.
- Indication expanded
Indication expansion: LUTETIUM LU 177 VIPIVOTIDE TETRAXETAN (NDA215833)
- Label change
Label change: LUTETIUM LU 177 VIPIVOTIDE TETRAXETAN (NDA215833)
- Indication expanded
Indication expansion: LUTETIUM LU 177 VIPIVOTIDE TETRAXETAN (NDA215833)
- Label change
Label change: LUTETIUM LU 177 VIPIVOTIDE TETRAXETAN (NDA215833)
- Regulatory approval
Approval: LUTETIUM LU 177 VIPIVOTIDE TETRAXETAN (NDA215833)
- New publicationLutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.