Protein / target
Integrin alpha-2
Protein at a glance
Biological role
Collagen binding involved in cell-matrix adhesion
Strongest disease association
Heart Diseases
Therapeutic position
Clinically advancing target
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin.
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Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix
Subcellular location
Domains and Gene Ontology detail (60)Hide
Domains & features
Gene Ontology
- Caxon terminus
- Cbasal part of cell
- Ccell surface
- Cexternal side of plasma membrane
- Cfocal adhesion
- Cintegrin alpha2-beta1 complex
- Cintegrin complex
- Cperinuclear region of cytoplasm
- Cplasma membrane
- Famyloid-beta binding
- Fcollagen binding
- Fcollagen binding involved in cell-matrix adhesion
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Cell migration
- ·positive regulation of epithelial cell migration
- ·positive regulation of positive chemotaxis
- ·positive regulation of smooth muscle cell migration
- ·substrate-dependent cell migration
Cell adhesion
- ·Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fib…
- ·cell adhesion
- ·cell adhesion mediated by integrin
- ·cell-cell adhesion
Haemostasis
- ·Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fib…
- ·blood coagulation
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene ITGA2
Gene-level evidence surfaced through the gene ITGA2that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
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The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Drug development
1 compounds recorded · 1 in clinical development
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Open Targets known-drugs universe. Drug name and highest clinical stage only — the disease relationship is NOT read from this slice (it carries trial-context noise); approved indications come from the canonical graph above.
Tractability
Small molecules — Emerging
Antibodies — Strong
Protein degraders — Emerging
View underlying tractability evidence (8)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.