Protein / target
Killer cell immunoglobulin-like receptor 2DL2
Protein at a glance
Biological role
Transmembrane signaling receptor
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes.
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Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis
Subcellular location
Domains and Gene Ontology detail (6)Hide
Domains & features
Gene Ontology
- Cplasma membrane
- Fimmune receptor activity
- Ftransmembrane signaling receptor activity
- Pimmune response-inhibiting cell surface receptor signaling pathway
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Drugs targeting this protein
How approved and investigational drugs engage this protein — mechanism and action type, direct vs complex targeting, and how broadly each acts across other targets. A drug-first view (the section above groups the approved ones disease-first); direct binders with few recorded targets are listed first.
Killer cell immunoglobulin-like receptor 2DL2 inhibitor
ChEMBL mechanism, action type, target identity and approved indications. Open Targets clinical status.
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein. Ranked by active status, then clinical phase and recency, and spread across the targeting drugs.
View all trials (7)Hide
ClinicalTrials.gov via the drug-target graph.