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Protein / target

Killer cell immunoglobulin-like receptor 2DL2

Encoded byKIR2DL2P43627Homo sapiensSwiss-Prot
11
Clinical trials
1
Drugs targeting

Protein at a glance

Biological role

Transmembrane signaling receptor

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes.

View complete UniProt function annotation

Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis

Subcellular location

Cell membrane
Domains and Gene Ontology detail (6)

Domains & features

Ig-like C2-type 1Ig-like C2-type 2

Gene Ontology

  • Cplasma membrane
  • Fimmune receptor activity
  • Ftransmembrane signaling receptor activity
  • Pimmune response-inhibiting cell surface receptor signaling pathway

348 aa · 38 kDa

Biological roles

Reactome v97

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

View underlying pathways (1)

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Drugs targeting this protein

1

How approved and investigational drugs engage this protein — mechanism and action type, direct vs complex targeting, and how broadly each acts across other targets. A drug-first view (the section above groups the approved ones disease-first); direct binders with few recorded targets are listed first.

lirilumab
Narrow target profileInhibitor

Killer cell immunoglobulin-like receptor 2DL2 inhibitor

Direct interaction with this protein · 1 of 3 recorded protein targets — narrow recorded profile

ChEMBL mechanism, action type, target identity and approved indications. Open Targets clinical status.

Clinical trials

11

Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein. Ranked by active status, then clinical phase and recency, and spread across the targeting drugs.

View all trials (7)

ClinicalTrials.gov via the drug-target graph.