Back to discover

Protein / target

Lysosome-associated membrane glycoprotein 3

Encoded byLAMP3Q9UQV4Homo sapiensSwiss-Prot
UniProt: Q9UQV4Ensembl: ENSG00000078081HGNC: HGNC:14582NCBI Gene: 27074
Antibody-tractable
Druggability
UniProt loc high conf
1
Research papers

Protein at a glance

Biological role

Negative regulation of proteasomal protein catabolic process

Strongest disease association

Alcohol drinking

Via encoding gene LAMP3 · Genetic evidence · score 0.45

Research activity

Emerging research

1 papers · latest 2020

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction.

View complete UniProt function annotation

Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718). Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532). May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752)

Subcellular location

Cell surfaceLysosome membraneCytoplasmic vesicle membraneEarly endosome membrane
Domains and Gene Ontology detail (16)

Gene Ontology

  • Calveolar lamellar body membrane
  • Ccell surface
  • Cearly endosome
  • Cearly endosome membrane
  • Clate endosome membrane
  • Clysosomal membrane
  • Cperinuclear region of cytoplasm
  • Cplasma membrane
  • Cvesicle
  • Padaptive immune response
  • Pestablishment of protein localization to organelle
  • Pnegative regulation of proteasomal protein catabolic process

416 aa · 44 kDa

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Cell proliferation & survivalUniProt
View supporting evidence

Cell proliferation & survival

  • ·Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR…

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene LAMP3

Gene-level evidence surfaced through the gene LAMP3 that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Alcohol drinking
0.45Limited support

Genetic evidence dominant · Open Targets 0.27

Heart Diseases
0.43Limited support

Genetic evidence dominant · Open Targets 0.26

Liver Diseases
0.42Limited support

Genetic evidence dominant · Open Targets 0.26

Parkinson's Disease
0.25Limited support

Genetic evidence dominant · Open Targets 0.14

Neoplasms
0.14Preliminary

Literature evidence dominant · Open Targets 0.11 · no direct causal or clinical evidence

View evidence synthesis (5)
Alcohol drinkingLimited support
0.45
agreement 0.33–0.57
Genetic100%

Open Targets aggregate 0.27 · 1 independent evidence family

Heart DiseasesLimited support
0.43
agreement 0.31–0.55
Genetic100%

Open Targets aggregate 0.26 · 1 independent evidence family

Liver DiseasesLimited support
0.42
agreement 0.29–0.56
Genetic99%Literature1%

Open Targets aggregate 0.26 · 2 independent evidence families

Parkinson's DiseaseLimited support
0.25
agreement 0.11–0.39
Genetic80%Literature20%

Open Targets aggregate 0.14 · 2 independent evidence families

NeoplasmsPreliminary
0.14
agreement 0.00–0.41
Literature100%

Open Targets aggregate 0.11 · 1 independent evidence family · no direct causal or clinical evidence

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Alcohol drinking0.27
Heart Diseases0.26
Liver Diseases0.26
Parkinson's Disease0.14
Neoplasms0.11
Esophageal Squamous Cell Carcinoma0.08

Tractability

Antibodies — Emerging

Feasibility evidence (uniprot loc high conf and go cc high conf) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (3)
AB · UniProt loc high confAB · GO CC high confAB · UniProt SigP or TMHMM

Raw Open Targets tractability assessment buckets, by modality.

Research activity

1 papers · to 2020

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.485 cites

Chen Z · Nature communications · 2020

Recent

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.

Chen Z · Nature communications · 2020

Europe PMC papers linked directly to this protein.