Protein / target
Natural killer cells antigen CD94
Protein at a glance
Biological role
HLA-E specific inhibitory MHC class Ib receptor
Strongest disease association
Neoplasms
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Immune receptor involved in self-nonself discrimination.
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Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules (PubMed:10023772, PubMed:18064301, PubMed:18083576, PubMed:37264229, PubMed:9486650, PubMed:9754572). Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:12387742, PubMed:18064301, PubMed:9430220). Primarily functions as a ligand binding subunit as it lacks the capacity to signal
Subcellular location
Domains and Gene Ontology detail (20)Hide
Domains & features
Gene Ontology
- Ccell surface
- Cexternal side of plasma membrane
- Cplasma membrane
- Creceptor complex
- Fcarbohydrate binding
- FHLA-A specific activating MHC class I receptor activity
- FHLA-E specific inhibitory MHC class Ib receptor activity
- FMHC class I protein complex binding
- FMHC class Ib protein binding, via antigen binding groove
- Fprotein antigen binding
- Ftransmembrane signaling receptor activity
- Padaptive immune response
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Immune signalling
- ·MHC class Ib protein binding, via antigen binding groove
- ·protein antigen binding
- ·adaptive immune response
- ·negative regulation of T cell mediated cytotoxicity
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene KLRD1
Gene-level evidence surfaced through the gene KLRD1 that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
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The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Tractability
Antibodies — Emerging
View underlying tractability evidence (3)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.