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Protein / target

Netrin-1

Encoded byNTN1O95631Homo sapiensSwiss-Prot
UniProt: O95631Ensembl: ENSG00000065320HGNC: HGNC:8029NCBI Gene: 9423
Small-molecule tractable
Druggability
Structure with Ligand
1
Research papers

Protein at a glance

Biological role

Substrate-dependent cell migration, cell extension

Strongest disease association

Cleft Palate

Via encoding gene NTN1 · Genetic evidence · score 0.61

Research activity

Emerging research

1 papers · latest 2024

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Netrins control guidance of CNS commissural axons and peripheral motor axons.

View complete UniProt function annotation

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335)

Subcellular location

SecretedCytoplasm
Domains and Gene Ontology detail (20)

Domains & features

Laminin N-terminalLaminin EGF-like 1Laminin EGF-like 2Laminin EGF-like 3NTR

Gene Ontology

  • Cbasement membrane
  • Ccytosol
  • Cextracellular region
  • Cglutamatergic synapse
  • FDNA-binding transcription factor activity, RNA polymerase II-specific
  • FRNA polymerase II cis-regulatory region sequence-specific DNA binding
  • Papoptotic process
  • PCdc42 protein signal transduction
  • Pchemorepulsion of axon
  • Ppositive regulation of axon extension
  • Ppositive regulation of cell motility
  • PRas protein signal transduction

604 aa · 68 kDa

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Synaptic signallingGOCell migrationGOOncogenic signallingUniProtTranscriptional regulationGO
View supporting evidence

Synaptic signalling

  • ·glutamatergic synapse
  • ·regulation of synapse assembly

Cell migration

  • ·positive regulation of cell motility
  • ·substrate-dependent cell migration, cell extension

Oncogenic signalling

  • ·Netrins control guidance of CNS commissural axons and peripheral motor axons. Its associ…

Transcriptional regulation

  • ·DNA-binding transcription factor activity, RNA polymerase II-specific
  • ·RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • ·regulation of transcription by RNA polymerase II

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene NTN1

Gene-level evidence surfaced through the gene NTN1that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Cleft Palate
0.70Moderately supported

Genetic evidence dominant · Open Targets 0.47

Cleft Lip
0.68Moderately supported

Genetic evidence dominant · Open Targets 0.47

Placental abruption
0.47Limited support

Genetic evidence dominant · Open Targets 0.29

Response to antihypertensive drug
0.46Limited support

Genetic evidence dominant · Open Targets 0.28

View evidence synthesis (4)
Cleft PalateModerately supported
0.70
agreement 0.58–0.82
Genetic72%Animal model27%Literature1%

Open Targets aggregate 0.47 · 3 independent evidence families

Cleft LipModerately supported
0.68
agreement 0.56–0.80
Genetic77%Animal model19%Literature5%

Open Targets aggregate 0.47 · 3 independent evidence families

Placental abruptionLimited support
0.47
agreement 0.35–0.59
Genetic100%

Open Targets aggregate 0.29 · 1 independent evidence family

Response to antihypertensive drugLimited support
0.46
agreement 0.34–0.58
Genetic100%

Open Targets aggregate 0.28 · 1 independent evidence family

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Cleft Palate0.47
Cleft Lip0.47
Placental abruption0.29
Response to antihypertensive drug0.28

Tractability

Small molecules — Emerging

Feasibility evidence (structure with ligand) — no clinical-stage drug of this modality recorded.

Antibodies — Emerging

Feasibility evidence (uniprot loc high conf and go cc high conf) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (4)
SM · Structure with LigandAB · UniProt loc high confAB · GO CC high confAB · UniProt SigP or TMHMM

Raw Open Targets tractability assessment buckets, by modality.

Research activity

1 papers · to 2024

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1.7 cites

McCormick LE · Molecular biology of the cell · 2024

Recent

The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1.

McCormick LE · Molecular biology of the cell · 2024

Europe PMC papers linked directly to this protein.