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Protein / target

Neurotrophin-3

Encoded byNTF3P20783Homo sapiensSwiss-Prot
UniProt: P20783Ensembl: ENSG00000185652HGNC: HGNC:8023NCBI Gene: 4908
Antibody-tractable
Druggability
GO CC high conf
3
Research papers

Protein at a glance

Biological role

Nerve growth factor receptor binding

Strongest disease association

Breast Neoplasms

Via encoding gene NTF3 · Genetic evidence · score 0.50

Research activity

Emerging research

3 papers · latest 2003

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Seems to promote the survival of visceral and proprioceptive sensory neurons

Subcellular location

Secreted
Domains and Gene Ontology detail (23)

Gene Ontology

  • Cextracellular region
  • Cextracellular space
  • Csynaptic vesicle
  • Fchemoattractant activity
  • Fgrowth factor activity
  • Fnerve growth factor receptor binding
  • Fsignaling receptor binding
  • Pcell surface receptor protein tyrosine kinase signaling pathway
  • Pcell-cell signaling
  • Pinduction of positive chemotaxis
  • Pmodulation of chemical synaptic transmission
  • Pnegative regulation of neuron apoptotic process

257 aa · 29 kDa · 2 isoforms

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Cell migrationGOSynaptic signallingGOReceptor tyrosine kinase signallingGOCell proliferation & survivalGOApoptosis & cell deathGO
View supporting evidence

Cell migration

  • ·induction of positive chemotaxis
  • ·positive regulation of cell migration

Synaptic signalling

  • ·modulation of chemical synaptic transmission

Receptor tyrosine kinase signalling

  • ·cell surface receptor protein tyrosine kinase signaling pathway

Cell proliferation & survival

  • ·positive regulation of cell population proliferation

Apoptosis & cell death

  • ·negative regulation of neuron apoptotic process
  • ·regulation of apoptotic process

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene NTF3

Gene-level evidence surfaced through the gene NTF3that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Breast Neoplasms
0.55Moderately supported

Genetic evidence dominant · Open Targets 0.32

Neuroendocrine Tumors
0.50Limited support

Genetic evidence dominant · Open Targets 0.30

Von Willebrand disease
0.44Limited support

Genetic evidence dominant · Open Targets 0.21

Diabetic Ketoacidosis
0.40Limited support

Genetic evidence dominant · Open Targets 0.24

Drug Hypersensitivity
0.40Limited support

Genetic evidence dominant · Open Targets 0.24

View evidence synthesis (5)
Breast NeoplasmsModerately supported
0.55
agreement 0.42–0.68
Genetic83%Literature9%RNA expression9%

Open Targets aggregate 0.32 · 3 independent evidence families

Neuroendocrine TumorsLimited support
0.50
agreement 0.38–0.62
Genetic100%

Open Targets aggregate 0.30 · 1 independent evidence family

Von Willebrand diseaseLimited support
0.44
agreement 0.32–0.56
Genetic64%Animal model36%

Open Targets aggregate 0.21 · 2 independent evidence families

Diabetic KetoacidosisLimited support
0.40
agreement 0.28–0.52
Genetic100%

Open Targets aggregate 0.24 · 1 independent evidence family

Drug HypersensitivityLimited support
0.40
agreement 0.28–0.52
Genetic100%

Open Targets aggregate 0.24 · 1 independent evidence family

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations
Neoplasms0.37
Breast Neoplasms0.32
Neuroendocrine Tumors0.30
Diabetic Ketoacidosis0.24
Drug Hypersensitivity0.24
Von Willebrand disease0.21
Blood Coagulation Disorders0.12

Tractability

Antibodies — Emerging

Feasibility evidence (go cc high conf and uniprot loc med conf) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (3)
AB · GO CC high confAB · UniProt loc med confAB · UniProt SigP or TMHMM

Raw Open Targets tractability assessment buckets, by modality.

Research activity

3 papers · to 2003

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.1,194 cites

Shirayama Y · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus.1,001 cites

Smith MA · The Journal of neuroscience : the official journal of the Society for Neuroscience · 1995

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.593 cites

Saarelainen T · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003

Recent

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.

Saarelainen T · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.

Shirayama Y · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus.

Smith MA · The Journal of neuroscience : the official journal of the Society for Neuroscience · 1995

Europe PMC papers linked directly to this protein.