Protein / target

Presenilin-1

PSEN1P49768
UniProt: P49768
10
Research papers

Protein at a glance

Research activity

Emerging research

10 papers · latest 2025

Derived from structured UniProt, Open Targets and literature data on this page.

Research activity

10 papers · to 2025

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders.1,170 cites

Palmqvist S · JAMA · 2020

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.546 cites

McClean PL · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011

Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice.379 cites

Sun J · Translational psychiatry · 2019

Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.15 cites

Benzow K · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024

Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model.14 cites

Kommaddi RP · The Journal of biological chemistry · 2024

Recent

Alpha-Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease.

Navakkode S · Aging cell · 2025

Treadmill Exercise Facilitates Synaptic Plasticity in <i>APP/PS1</i> Mice by Regulating Hippocampal AMPAR Activity.

Yu L · Cells · 2024

Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.

Benzow K · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024

Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer's disease.

Abdulhameed N · Alzheimer's research & therapy · 2024

Early-life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism.

Kotah JM · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024

Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model.

Kommaddi RP · The Journal of biological chemistry · 2024

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice.

Gomez-Murcia V · Brain : a journal of neurology · 2024

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders.

Palmqvist S · JAMA · 2020

Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice.

Sun J · Translational psychiatry · 2019

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

McClean PL · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011

Europe PMC papers linked directly to this protein.