Protein / target

Pro-neuropeptide Y

Encoded byNPYP01303Homo sapiensSwiss-Prot

UniProt: P01303 Ensembl: ENSG00000122585 HGNC: HGNC:7955 NCBI Gene: 4852

Antibody-tractable

Druggability

GO CC high conf

Research papers

Protein at a glance

Biological role

G protein-coupled receptor

Strongest disease association

Alcohol drinking

Via encoding gene NPY · Genetic evidence · score 0.52

Research activity

Emerging research

3 papers · latest 2025

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function overview

Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R).

View complete UniProt function annotation

Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1321422, PubMed:7592910, PubMed:35165283, PubMed:35507650, PubMed:36525977, PubMed:38882210). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1321422, PubMed:7592910, PubMed:38882210). Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels (PubMed:1321422, PubMed:35165283, PubMed:7592910). Is involved in the regulation of eating behaviour, acting as a stimulator of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)

Subcellular location

SecretedCytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle

Domains and Gene Ontology detail (43)

Gene Ontology

Cextracellular region
Cextracellular space
CGABA-ergic synapse
CGolgi apparatus
Cneuronal dense core vesicle
Cperikaryon
Cperinuclear region of cytoplasm
Cterminal bouton
Fcalcium channel regulator activity
FG protein-coupled receptor activity
Fneuropeptide activity
Fneuropeptide hormone activity

97 aa · 11 kDa

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

Synaptic signallingGOCell proliferation & survivalGOG protein-coupled signallingUniProt · GO

View supporting evidence

Synaptic signalling

·GABA-ergic synapse
·chemical synaptic transmission
·regulation of presynaptic cytosolic calcium ion concentration

Cell proliferation & survival

·positive regulation of cell population proliferation

G protein-coupled signalling

·Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NP…
·G protein-coupled receptor activity
·adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
·G protein-coupled receptor signaling pathway

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Translational evidence

Open Targets 26

Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.

Strongest disease associations · via encoding gene NPY

Gene-level evidence surfaced through the gene NPYthat encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.

Alcohol drinking

0.55Moderately supported

Genetic evidence dominant · Open Targets 0.33

Stroke

0.55Moderately supported

Genetic evidence dominant · Open Targets 0.33

Nephritis

0.52Moderately supported

Genetic evidence dominant · Open Targets 0.32

Scoliosis

0.51Moderately supported

Genetic evidence dominant · Open Targets 0.31

Male reproductive organ cancer

0.49Limited support

Genetic evidence dominant · Open Targets 0.30

View evidence synthesis (5)

Alcohol drinkingModerately supported

0.55

agreement 0.41–0.69

Genetic89%Literature11%

Open Targets aggregate 0.33 · 2 independent evidence families

StrokeModerately supported

0.55

agreement 0.41–0.69

Genetic87%Literature13%

Open Targets aggregate 0.33 · 2 independent evidence families

NephritisModerately supported

0.52

agreement 0.40–0.64

Genetic100%

Open Targets aggregate 0.32 · 1 independent evidence family

ScoliosisModerately supported

0.51

agreement 0.39–0.63

Genetic100%

Open Targets aggregate 0.31 · 1 independent evidence family

Male reproductive organ cancerLimited support

0.49

agreement 0.35–0.63

Genetic100%Literature0%

Open Targets aggregate 0.30 · 2 independent evidence families

The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.

Show all associations

Alcohol drinking0.33

Stroke0.33

Nephritis0.32

Scoliosis0.31

Male reproductive organ cancer0.30

Intelligence0.29

Neurodegenerative Diseases0.28

Tractability

Antibodies — Emerging

Feasibility evidence (go cc high conf and uniprot loc med conf) — no clinical-stage drug of this modality recorded.

View underlying tractability evidence (3)