Protein / target
Progesterone receptor
Protein at a glance
Biological role
Estrogen response element binding
Primary system
Endocrine & metabolic
Strongest disease association
endometriosis
Therapeutic maturity
Clinically validated target
Druggability
Small molecule
Clinical development
23 approved · 7 in clinical development
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor
Subcellular location
Domains and Gene Ontology detail (33)Hide
Domains & features
Gene Ontology
- Cchromatin
- Ccytosol
- Cmitochondrial outer membrane
- Cnucleoplasm
- Cnucleus
- Cplasma membrane
- FATPase binding
- FDNA binding
- FDNA-binding transcription activator activity, RNA polymerase II-specific
- FDNA-binding transcription factor activity, RNA polymerase II-specific
- Fenzyme binding
- Festrogen response element binding
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
Transcriptional regulation
- ·The steroid hormones and their receptors are involved in the regulation of eukaryotic ge…
- ·DNA-binding transcription activator activity, RNA polymerase II-specific
- ·DNA-binding transcription factor activity, RNA polymerase II-specific
- ·RNA polymerase II cis-regulatory region sequence-specific DNA binding
Nuclear receptor signalling
- ·DNA-binding transcription factor activity, RNA polymerase II-specific
- ·nuclear receptor activity
- ·nuclear receptor-mediated steroid hormone signaling pathway
- ·HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Kinase signalling
- ·negative regulation of phosphorylation
Immune signalling
- ·The steroid hormones and their receptors are involved in the regulation of eukaryotic ge…
View underlying pathways (7)Hide underlying pathways
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Interaction neighbourhood
Proteins with the strongest functional or physical association. Node size and line weight reflect STRING confidence; hover or select a partner to inspect one association.
Functional and physical associations from STRING v12.0. Only associations with this protein are drawn — partner-to-partner links are not part of this evidence.
Drugs targeting this protein
Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.
Progesterone receptor agonist
Appears in clinical studies involving amenorrhea, atypical endometrial hyperplasia, hemorrhage, Infertility
Progesterone receptor agonist
Appears in clinical studies involving prostate cancer, Hot flashes, prostate adenocarcinoma, endometriosis
Progesterone receptor agonist
Appears in clinical studies involving renal carcinoma, endometriosis, hemorrhage, hyperplasia
Progesterone receptor antagonist
Appears in clinical studies involving Cushing syndrome, psychotic disorder, major depressive disorder, Uterine leiomyoma
ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.
Translational evidence
Why this target matters therapeutically — disease associations, drugs in development, tractability and safety, from Open Targets.
Strongest genetic associations
Human genetic evidence — the most direct causal link between this target and a disease.
Highest-confidence therapeutic associations
Diseases where a drug acting on this target has already reached clinical development.
Highest overall evidence
Remaining associations by Open Targets' aggregated evidence score.
Show all associationsHide all associations
Open Targets ranks 2,083 associations for this target and we store the top 10 by aggregated score. The long tail is largely literature co-mention and RNA-expression evidence, not evidence that this target drives those diseases.
Known drugs · 31 total
Cushing syndrome · psychotic disorder · major depressive disorder
contraception · Uterine leiomyoma · uterine corpus leiomyoma
contraception · ovulation
Menorrhagia · osteoporosis · contraception
acne · contraception · anorexia nervosa
Menorrhagia · hemorrhage · contraception
endometriosis · Dysmenorrhea · Ovarian Hyperandrogenism
prostate cancer · Hot flashes · prostate adenocarcinoma
premature birth · preeclampsia · placenta praevia
contraception · pregnancy
Tractability
Safety liabilities
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.
Show remaining trials (24)Hide
ClinicalTrials.gov via the drug-target graph.
Related literature
Papers indexed under “Receptors, Progesterone” — a subject heading that covers this protein without being specific to it. Shown as context; not counted as this protein's own research activity.
Europe PMC literature, reached through a MeSH descriptor linked to this protein.
Forefront confidence
Our own weighting of the evidence behind each disease association. Human genetics and clinical evidence count for most; literature co-mention counts for little, because two entities sharing an abstract is not evidence that one drives the other.
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the underlying per-type scores are shown above so the calculation can be checked.
What's happening now
Recent activity around this target, drawn from one canonical event stream. Every item is reached through 4 drugs that target this protein, so each event is news about that drug rather than about the protein directly.
- Regulatory actionBiotech industry leaders file brief backing FDA against ‘malicious’ mifepristone challenge
- Supplemental approval
Supplemental approval: PROGESTERONE (NDA022057)
- Label change
Label change: PROGESTERONE (NDA022057)
- New publicationMetabolic control of luteinizing hormone-responsive ovarian steroidogenesis.
- New publicationSex hormones differently regulate lipid metabolism genes in primary human hepatocytes.
- Product recall
Recall (Class II): PROGESTERONE
- New publicationDiagnostic and therapeutic use of oral micronized progesterone in endocrinology.
- New publicationDisturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation.
- New publicationThe role of maternal hormones in regulating autonomic functions during pregnancy.
- New publicationMammary Microvessels are Sensitive to Menstrual Cycle Sex Hormones.
- New publicationMenstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology.
- New publicationAnorexia nervosa and adrenal hormones: a systematic review and meta-analysis.
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.