Protein / target
Progesterone receptor
Protein at a glance
Biological role
Estrogen response element binding
Strongest disease association
Endometriosis
Therapeutic position
Established drug target
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
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The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor
Subcellular location
Domains and Gene Ontology detail (33)Hide
Domains & features
Gene Ontology
- Cchromatin
- Ccytosol
- Cmitochondrial outer membrane
- Cnucleoplasm
- Cnucleus
- Cplasma membrane
- FATPase binding
- FDNA binding
- FDNA-binding transcription activator activity, RNA polymerase II-specific
- FDNA-binding transcription factor activity, RNA polymerase II-specific
- Fenzyme binding
- Festrogen response element binding
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Nuclear receptor signalling
- ·nuclear receptor activity
- ·nuclear receptor-mediated steroid hormone signaling pathway
- ·HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
- ·Nuclear Receptor transcription pathway
Receptor tyrosine kinase signalling
- ·Nuclear signaling by ERBB4
Transcriptional regulation
- ·The steroid hormones and their receptors are involved in the regulation of eukaryotic ge…
- ·DNA-binding transcription activator activity, RNA polymerase II-specific
- ·DNA-binding transcription factor activity, RNA polymerase II-specific
- ·RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Interaction neighbourhood
Proteins with the strongest functional or physical association. Node size and line weight reflect STRING confidence; hover or select a partner to inspect one association.
Functional and physical associations from STRING v12.0. Only associations with this protein are drawn — partner-to-partner links are not part of this evidence.
Approved medicines with mapped indications
Approved therapies targeting this protein, grouped by what they are approved to treat — the disease-first view of the medicines below. Relationships come from the canonical approved-indication graph (ChEMBL phase-4), the same source as the drug cards.
Broader indication categories (1)Hide
Broad umbrella indications (e.g. “Neoplasms”). Shown here because every medicine also appears under a more specific disease above — kept for completeness, de-emphasised for clarity.
23 medicines meet Open Targets' target-level approved-medicine definition; the 3 shown here are those on this page with a canonical approved disease indication in the graph. Approved indications from ChEMBL (phase-4), via the canonical drug→disease graph.
Drugs targeting this protein
How approved and investigational drugs engage this protein — mechanism and action type, direct vs complex targeting, and how broadly each acts across other targets. A drug-first view (the section above groups the approved ones disease-first); direct binders with few recorded targets are listed first.
Progesterone receptor agonist
Indicated for Amenorrhea, Endometrial Hyperplasia, Uterine Hemorrhage
Progesterone receptor agonist
Progesterone receptor agonist
Indicated for Carcinoma, Renal Cell, Endometriosis, Hyperplasia, Uterine Hemorrhage
Progesterone receptor antagonist
Indicated for Cushing's Syndrome
ChEMBL mechanism, action type, target identity and approved indications. Open Targets clinical status.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene PGR
Gene-level evidence surfaced through the gene PGR that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
View evidence synthesis (2)Hide
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Drug development
31 compounds recorded · 23 approved · 7 in clinical development · 1 earlier-stage
View all recorded compounds (10)Hide
Open Targets known-drugs universe. Drug name and highest clinical stage only — the disease relationship is NOT read from this slice (it carries trial-context noise); approved indications come from the canonical graph above.
Tractability
Small molecules — Strong
Antibodies — Emerging
Protein degraders — Emerging
View underlying tractability evidence (9)Hide
Raw Open Targets tractability assessment buckets, by modality.
Safety-related annotations
Terms indexed against this target in Open Targets' safety data, with their datasource. These are annotations, not causal claims: the direction of effect (whether activation or inhibition is implicated), species and evidence strength are not captured here, so an entry does not mean that modulating this target is known to cause that condition.
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein. Ranked by active status, then clinical phase and recency, and spread across the targeting drugs.
View all trials (26)Hide
ClinicalTrials.gov via the drug-target graph.
What's happening now
Recent therapeutic activity around this target — regulatory actions, clinical trials and safety signals for 3 drugs that target this protein, plus publications where such a drug is a genuine subject. Every item is reached indirectly through the drug, not the protein itself; incidental mentions (a paper that merely measures a drug) and press items are excluded.
- Trial status changed
A Multi-center, Open Label, Randomized Parallel Group Study Evaluating the Proportion of Women With Complete Resolution of Nonatypical Endometrial Hyperplasia Treated With Mirena or Oral Medroxyprogesterone Acetate for 6 Months
- Supplemental approval
Supplemental approval: PROGESTERONE (NDA022057)
- Label change
Label change: PROGESTERONE (NDA022057)
- Product recall
Recall (Class II): PROGESTERONE
- New publicationDiagnostic and therapeutic use of oral micronized progesterone in endocrinology.
- New publicationMammary Microvessels are Sensitive to Menstrual Cycle Sex Hormones.
- New publicationMenstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology.
- New publicationAnorexia nervosa and adrenal hormones: a systematic review and meta-analysis.
- New publicationMenopausal hormone therapy and change in physical activity in the Women's Health Initiative hormone therapy clinical trials.
- Safety communication
Drug Safety Update: Cyproterone acetate: new advice to minimise risk of meningioma
- Supplemental approval
Supplemental approval: PROGESTERONE (NDA022057)
- Regulatory approval
Approval: PROGESTERONE (NDA022057)
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.