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Protein / target

Reverse transcriptase

reverse transcriptaseQ06347Human immunodeficiency virus 2
11
Clinical trials
1
Drugs targeting

Protein at a glance

Biological role

Aspartic-type endopeptidase

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Domains and Gene Ontology detail (9)

Domains & features

Reverse transcriptaseRNase H type-1

Gene Ontology

  • Faspartic-type endopeptidase activity
  • FRNA stem-loop binding
  • FRNA-directed DNA polymerase activity
  • FRNA-DNA hybrid ribonuclease activity
  • PDNA integration
  • PDNA recombination
  • Pproteolysis

560 aa · 65 kDa

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

ProteolysisGO
View supporting evidence

Proteolysis

  • ·aspartic-type endopeptidase activity
  • ·proteolysis

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Drugs targeting this protein

1

How approved and investigational drugs engage this protein — mechanism and action type, direct vs complex targeting, and how broadly each acts across other targets. A drug-first view (the section above groups the approved ones disease-first); direct binders with few recorded targets are listed first.

Azvudine
Narrow target profileInhibitor

Reverse transcriptase inhibitor

Direct interaction with this protein · 1 of 3 recorded protein targets — narrow recorded profile

ChEMBL mechanism, action type, target identity and approved indications. Open Targets clinical status.

Clinical trials

11

Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein. Ranked by active status, then clinical phase and recency, and spread across the targeting drugs.

ClinicalTrials.gov via the drug-target graph.