Protein / target

Serine/threonine-protein kinase mTOR

MTORP42345
UniProt: P42345
32
Research papers

Protein at a glance

Research activity

Actively researched

32 papers · latest 2024

Derived from structured UniProt, Open Targets and literature data on this page.

Research activity

32 papers · to 2024

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Comprehensive molecular characterization of urothelial bladder carcinoma.2,303 cites

Nature · 2014

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.1,718 cites

Michalek RD · Journal of immunology (Baltimore, Md. : 1950) · 2011

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells.1,476 cites

Shi LZ · The Journal of experimental medicine · 2011

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer.1,279 cites

Glaviano A · Molecular cancer · 2023

Reprogramming of fatty acid metabolism in cancer.1,271 cites

Koundouros N · British journal of cancer · 2020

Recent

PI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer.

Zhang HP · Breast cancer (Tokyo, Japan) · 2024

PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment.

Leiphrakpam PD · International journal of molecular sciences · 2024

Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer.

Morgos DT · International journal of molecular sciences · 2024

The Genetics of Tuberous Sclerosis Complex and Related mTORopathies: Current Understanding and Future Directions.

Man A · Genes · 2024

Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.

Zhao R · The Journal of cell biology · 2024

TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.

Zhang N · Cell death & disease · 2024

Pharmacological inhibition of S6K1 rescues synaptic deficits and attenuates seizures and depression in chronic epileptic rats.

Zhang Y · CNS neuroscience & therapeutics · 2024

PI3K-AKT/mTOR Signaling in Psychiatric Disorders: A Valuable Target to Stimulate or Suppress?

Chen Y · The international journal of neuropsychopharmacology · 2024

Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model.

Kommaddi RP · The Journal of biological chemistry · 2024

The Metabolic Basis for Nervous System Dysfunction in Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease.

Maiese K · Current neurovascular research · 2023

Europe PMC papers linked directly to this protein.