Protein / target

Signal transducer and activator of transcription 3

STAT3P40763
UniProt: P40763
16
Research papers

Protein at a glance

Research activity

Emerging research

16 papers · latest 2025

Derived from structured UniProt, Open Targets and literature data on this page.

Research activity

16 papers · to 2025

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.1,428 cites

Fraietta JA · Nature medicine · 2018

IL-6 in inflammation, autoimmunity and cancer.978 cites

Hirano T · International immunology · 2021

The JAK-STAT signaling pathway: input and output integration.871 cites

Murray PJ · Journal of immunology (Baltimore, Md. : 1950) · 2007

Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial-Mesenchymal Transition.356 cites

Jin W · Cells · 2020

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.335 cites

Yin H · Nature communications · 2021

Recent

STAT3 Signaling Mediates Agomelatine Restoration of Prefrontal Cortex Synaptic Plasticity in Chronic Social Defeat Stress Mice.

Lee CW · Molecular neurobiology · 2025

Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery.

Hu Y · Journal of experimental & clinical cancer research : CR · 2024

RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.

Ganesh S · Molecular therapy : the journal of the American Society of Gene Therapy · 2024

The role of interleukin-6 family cytokines in cancer cachexia.

Agca S · The FEBS journal · 2024

Tumor-associated macrophage subtypes on cancer immunity along with prognostic analysis and SPP1-mediated interactions between tumor cells and macrophages.

Xu L · PLoS genetics · 2024

JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors.

Pennel KAF · Journal of experimental & clinical cancer research : CR · 2024

Tumor-Derived Extracellular Vesicles Enable Tumor Tropism Chemo-Genetherapy for Local Immune Activation in Triple-Negative Breast Cancer.

Peng Z · ACS nano · 2024

BDNF alleviates Parkinson's disease by promoting STAT3 phosphorylation and regulating neuronal autophagy.

Geng X · Cell and tissue research · 2023

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.

Pencik J · Molecular cancer · 2023

Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation <i>via</i> JAK2/STAT3 Pathway Inhibition.

Zhu H · Frontiers in immunology · 2021

Europe PMC papers linked directly to this protein.