Protein / target
Somatostatin receptor type 2
Protein at a glance
Biological role
Somatostatin receptor activity
Primary system
Nervous system
Strongest disease association
acromegaly
Therapeutic maturity
Clinically validated target
Druggability
Small molecule
Clinical development
7 approved · 7 in clinical development
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization
Subcellular location
Domains and Gene Ontology detail (11)Hide
Gene Ontology
- Ccytosol
- Cneuron projection
- Cplasma membrane
- Fneuropeptide binding
- FPDZ domain binding
- Fsomatostatin receptor activity
- Pcellular response to estradiol stimulus
- Pcellular response to glucocorticoid stimulus
- PG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- Pnegative regulation of cell population proliferation
- Pneuropeptide signaling pathway
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
G protein-coupled signalling
- ·G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messen…
Kinase signalling
- ·Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensi…
View underlying pathways (2)Hide underlying pathways
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Interaction neighbourhood
Proteins with the strongest functional or physical association. Node size and line weight reflect STRING confidence; hover or select a partner to inspect one association.
Functional and physical associations from STRING v12.0. Only associations with this protein are drawn — partner-to-partner links are not part of this evidence.
Drugs targeting this protein
Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.
Somatostatin receptor binding agent
ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.
Translational evidence
Why this target matters therapeutically — disease associations, drugs in development, tractability and safety, from Open Targets.
Highest-confidence therapeutic associations
Diseases where a drug acting on this target has already reached clinical development.
Highest overall evidence
Remaining associations by Open Targets' aggregated evidence score.
Show all associationsHide all associations
Open Targets ranks 1,327 associations for this target and we store the top 10 by aggregated score. The long tail is largely literature co-mention and RNA-expression evidence, not evidence that this target drives those diseases.
Known drugs · 14 total
carcinoid tumor · cancer · acromegaly
acromegaly · carcinoid syndrome
acromegaly · breast cancer
acromegaly · ACTH-dependent Cushing syndrome · ACTH-dependent Cushing syndrome
digestive system neuroendocrine tumor, grade 1/2 · neuroendocrine neoplasm · pheochromocytoma
acromegaly · carcinoid syndrome · neuroendocrine neoplasm
acromegaly · diabetic retinopathy · neuroendocrine neoplasm
autosomal dominant polycystic kidney disease · gallbladder carcinoma · thymoma
acromegaly
Tractability
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.
Show remaining trials (24)Hide
ClinicalTrials.gov via the drug-target graph.
Forefront confidence
Our own weighting of the evidence behind each disease association. Human genetics and clinical evidence count for most; literature co-mention counts for little, because two entities sharing an abstract is not evidence that one drives the other.
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the underlying per-type scores are shown above so the calculation can be checked.
What's happening now
Recent activity around this target, drawn from one canonical event stream. Every item is reached through a drug that targets this protein, so each event is news about that drug rather than about the protein directly.
- Regulatory approval
Approval: Lutathera (EMA)
- New publicationTreatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival.
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.