Protein / target

Toll-like receptor 4

TLR4O00206
UniProt: O00206
22
Research papers

Protein at a glance

Research activity

Emerging research

22 papers · latest 2025

Derived from structured UniProt, Open Targets and literature data on this page.

Research activity

22 papers · to 2025

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

TLR4 links innate immunity and fatty acid-induced insulin resistance.2,658 cites

Shi H · The Journal of clinical investigation · 2006

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.1,338 cites

Kadowaki N · The Journal of experimental medicine · 2001

HMGB1 is a therapeutic target for sterile inflammation and infection.1,173 cites

Andersson U · Annual review of immunology · 2011

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.1,041 cites

Ciesielska A · Cellular and molecular life sciences : CMLS · 2021

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.1,037 cites

Ohashi K · Journal of immunology (Baltimore, Md. : 1950) · 2000

Recent

Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).

Tsao LC · Nature communications · 2025

An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein-protein interactions.

Luo R · Cell communication and signaling : CCS · 2025

MiR129-5p-loaded exosomes suppress seizure-associated neurodegeneration in status epilepticus model mice by inhibiting HMGB1/TLR4-mediated neuroinflammation.

Liu T · Molecular biology reports · 2024

Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.

Mattke J · Frontiers in immunology · 2024

IRF3 function and immunological gaps in sepsis.

Basak B · Frontiers in immunology · 2024

Identification of immune biomarkers in recent active pulmonary tuberculosis.

Shaukat SN · Scientific reports · 2023

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation.

Aboudounya MM · Mediators of inflammation · 2021

Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis.

Zhao Z · Microbiome · 2021

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.

Ciesielska A · Cellular and molecular life sciences : CMLS · 2021

Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting.

Paudel YN · Cells · 2020

Europe PMC papers linked directly to this protein.