Aortic Diseases
Recent clinical, regulatory, research and industry developments relating to this disease.
Single-cell profiling reveals age-associated immunity in atherosclerosis.
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q4 2026.
- Q4 2026A Prospective, Randomized, Multicenter, Single-blind Trial to Assess the Safety and Effectiveness of the Encompass F2 Cerebral Protection System Vs. Standard of Care (Unprotected or Sentinel® Cerebral Protection System) During Transfemoral Transcatheter Aortic Valve Replacement
- Q4 2026Liposomal Bupivacaine/Bupivacaine A Single-Dose Bilateral Rectus Sheath Blocks Versus Ropivacaine in Bilateral Rectus Sheath Blocks And Catheters With Intermittent Hourly Boluses.
Clinical MilestonesViewHide
- 2025-11-20A Prospective, Randomized, Multicenter, Single-blind Trial to Assess the Safety and Effectiveness of the Encompass F2 Cerebral Protection System Vs. Standard of Care (Unprotected or Sentinel® Cerebral Protection System) During Transfemoral Transcatheter Aortic Valve ReplacementResults expected Q4 2026
- 2025-09-03Liposomal Bupivacaine/Bupivacaine A Single-Dose Bilateral Rectus Sheath Blocks Versus Ropivacaine in Bilateral Rectus Sheath Blocks And Catheters With Intermittent Hourly Boluses.Results expected Q4 2026
- 2025-11-20ClinicalA Prospective, Randomized, Multicenter, Single-blind Trial to Assess the Safety and Effectiveness of the Encompass F2 Cerebral Protection System Vs. Standard of Care (Unprotected or Sentinel® Cerebral Protection System) During Transfemoral Transcatheter Aortic Valve ReplacementResults expected Q4 2026
- 2025-09-03ClinicalLiposomal Bupivacaine/Bupivacaine A Single-Dose Bilateral Rectus Sheath Blocks Versus Ropivacaine in Bilateral Rectus Sheath Blocks And Catheters With Intermittent Hourly Boluses.Results expected Q4 2026
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Aortic Diseases2
- Aorta, Abdominal1
- Aorta, Thoracic1
- Atherosclerosis1
- Bicuspid Aortic Valve Disease1
- Cardiology1
- Cardiovascular Diseases1
- Plaque, Atherosclerotic1
Leading journals4
- European heart journal2
- Cardiovascular research1
- Circulation1
- Circulation research1
Leading researchers8
- Binder CJ2
- Iung B2
- Aboyans V1
- Allmen RS1
- Augoustides JG1
- Bartolomeo RD1
- Beck AW1
- Bernabé Kleijn MNA1
Affiliations (unnormalised)6
- Department of Laboratory Medicine2
- AHA/ACC Joint Committee on Clinical Data Standards liaison.1
- AHA/ACC Joint Committee on Clinical Practice Guidelines liaison.1
- Amsterdam University Medical Centers-location AMC1
- Berlin Institute of Health at Charité-Universitätsmedizin Berlin1
- Center for Immunology (J.W.W.)1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Aortic diseases are pathological processes involving any part of the aorta. The term covers multiple clinical presentation subsets, including asymptomatic, stable symptomatic, and acute aortic syndromes.
The supplied grounding does not define a single mechanism for all aortic diseases. One provided review of atherosclerotic mouse aortas describes prominent immune-cell infiltration, including macrophages, monocytes, neutrophils, dendritic cells, natural killer cells, innate lymphoid cells, and T-cell subsets, indicating an inflammatory component in at least some aortic disease contexts.
Management is described at the level of diagnosis, genetic evaluation and family screening, medical therapy, endovascular treatment, surgical treatment, and long-term surveillance. The guideline applies these approaches across asymptomatic, stable symptomatic, and acute aortic syndromes.
AI-generated summary grounded in MeSH and 2 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Pathological processes involving any part of the AORTA.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.