Aortic Valve Disease
Recent clinical, regulatory, research and industry developments relating to this disease.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q4 2026.
Clinical MilestonesViewHide
- 2026-06-26Controlled Arterial Protection to Ultimately Remove Embolic MaterialResults expected Q2 2028
- 2026-04-08Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation: a Prospective, Multicenter, Randomized StudyResults expected Q4 2026
- 2025-12-22Does Colchicine Reduce Progression of Aortic Valve Stenosis?Primary completion
- 2026-06-26ClinicalControlled Arterial Protection to Ultimately Remove Embolic MaterialResults expected Q2 2028
- 2026-04-08ClinicalTranscatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation: a Prospective, Multicenter, Randomized StudyResults expected Q4 2026
- 2025-12-22ClinicalDoes Colchicine Reduce Progression of Aortic Valve Stenosis?Primary completion
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes1
- Transcatheter Aortic Valve Replacement1
Leading journals1
- Journal of the American College of Cardiology1
Leading researchers8
- Alu MC1
- Bax JJ1
- Blackstone EH1
- Blanke P1
- Cohen DJ1
- Finn MT1
- Généreux P1
- Hahn RT1
Affiliations (unnormalised)6
- Baylor Scott & White Heart Hospital Plano1
- Beth Israel Deaconess Medical Center1
- Cleveland Clinic1
- Cleveland Clinic and Department of Quantitative Health Sciences1
- Columbia University Irving Medical Center/NewYork-Presbyterian Hospital and Cardiovascular Research Foundation1
- Gagnon Cardiovascular Institute1
Reference
Authoritative identity, definition & identifiers.
Diseases involving the AORTIC VALVE functionality. Aortic valve disease often results in a backward and/or regurgitated blood flow into the LEFT VENTRICLE or a decreased blood flow from the heart. It includes congenital (e.g., bicuspid aortic valve), syndromic, and acquired (e.g., age-related, infection-associated) conditions.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.