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ROBO4

Gene

roundabout guidance receptor 4

HGNCHGNC:17985EnsemblENSG00000154133NCBI Gene54538
Locus: gene with protein productLocation: 11q24.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFLJ20798 · MRB · ECSM4
View full nomenclature history (6)
Alias symbolsFLJ20798, MRB, ECSM4
Previous namesroundabout homolog 4 (Drosophila), roundabout, axon guidance receptor, homolog 4 (Drosophila)
Alias namesmagic roundabout

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Aortic Valve Disease
Neurodegenerative Diseases
Heart Arrest

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Fibronectin type III domain containingI-set domain containingRoundabout guidance receptor family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.