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Disease

Atrial fibrillation, familial, 10

Late-stage therapeutic development

Also known as SCN5A familial atrial fibrillation, atrial fibrillation, familial, type 10, familial atrial fibrillation caused by mutation in SCN5A, ATFB10.

23
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Clinical Milestones10View all 10
Results expected 3
Recently completed 5
Other updates 2
+2 more in the activity timeline below
Activity timeline10

Clinical trials

17 sponsors · 0 new · 4 completed in the last 12 months (net -2)

The current development programme across all trial phases.

Clinical programme
23
All trials
6
Active
17
Late-stage
6
Completed
Late-stage studies

Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure. The ANDES Trial

Phase 4 · Active, not recruiting · Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec

The Danish Non-vitamin K Antagonist Oral Anticoagulation Study. A Cluster Randomized Study Comparing Safety and Efficacy of Edoxaban, Apixaban, Rivaroxaban and Dabigatran for Oral Anticoagulation in Atrial Fibrillation (DANNOAC-AF).

Phase 4 · Active, not recruiting · Herlev and Gentofte Hospital

Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias

Phase 4 · Active, not recruiting · Vivek Reddy

Rationale and Design of Dabigatran for Mitral Stenosis Atrial Fibrillation Trial

Phase 4 · Active, not recruiting · The University of Hong Kong

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

Phase 4 · Active, not recruiting · Population Health Research Institute

Management of Anticoagulant Therapy Monitored by an Implantable Device With Telecardiology in Patients With Acute Coronary Syndrome Associated With de Novo Atrial Fibrillation Arrhythmia: A Prospective Multicenter Study

Phase 4 · Active, not recruiting · Centre Hospitalier de PAU
Recently completed

Stellate Ganglion Blockade for the Prevention of Atrial Fibrillation After Cardiac Surgery: A Randomized Placebo-Controlled Trial

Phase 2/3 · Completed · Mayo Clinic

Escalated Single Platelet Inhibition for One Month Plus Direct Oral Anticoagulation in Patients With Atrial Fibrillation and acUte coRonary Syndrome Undergoing percutaneoUS Coronary Intervention

Phase 4 · Completed · Ludwig-Maximilians - University of Munich

Sacubitril Valsartan in Preventing the Recurrence of Atrial Fibrillation After Ablation in Elderly Hypertensive Patients With Atrial Fibrillation

Phase 4 · Completed · Shanghai Jiao Tong University School of Medicine

A Trial of Pharmacist Management of Oral Anticoagulation THerapy Versus Enhanced Usual CARe in the communitY for AF (APOTHECARY AF Study)

Phase 4 · Completed · Cedars-Sinai Medical Center

An Open Label, Multi-center Trial to Evaluate the Feasibility and Safety of Short-term Treatment With Subcutaneously Injected Certoparin (8000 U Anti-Xa Twice Daily) in Patients With Persistent Nonvalvular Atrial Fibrillation

Phase 3 · Completed · Novartis

A Comparison of the Effectiveness of Carvedilol Versus Metoprolol for Atrial Fibrillation Appearing After Off-Pump Coronary Bypass Surgery in the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT)

N/A · Completed · Ministry of Health, Labour and Welfare, Japan

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

SCN5A0.80

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Sodium channel protein type 5 subunit alphavia SCN5A0.80

Reference

Authoritative identity, definition & identifiers.

Synonyms

SCN5A familial atrial fibrillation, atrial fibrillation, familial, type 10, familial atrial fibrillation caused by mutation in SCN5A, ATFB10

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.