SCN5A

Gene

sodium voltage-gated channel alpha subunit 5

HGNCHGNC:10593 EnsemblENSG00000183873 NCBI Gene6331

Locus: gene with protein productLocation: 3p22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium channel protein type 5 subunit alphaQ14524

Protein · therapeutic target

Clinically validated target · 66 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCMD1E · PFHB1 · HB1 · Nav1.5 · LQT3 · HBBD · IVF · HB2 · HH1 · SSS1 · CDCD2 · CMPD2 · ICCD

View full nomenclature history (17)

Previous symbolsCMD1E

Alias symbolsPFHB1, HB1, Nav1.5, LQT3, HBBD, IVF, HB2, HH1, SSS1, CDCD2, CMPD2, ICCD

Previous namessodium channel, voltage-gated, type V, alpha (long QT syndrome 3), sodium channel, voltage-gated, type V, alpha subunit, sodium channel, voltage gated, type V alpha subunit

Alias nameslong QT syndrome 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Brugada syndrome 1

long QT syndrome 3

Bundle-Branch Block

Atrial fibrillation, familial, 10

Brugada syndrome

dilated cardiomyopathy 1E

Familial progressive cardiac conduction defect

Arrhythmias, Cardiac

Sick sinus syndrome 1

Sudden infant death syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sodium voltage-gated channel alpha subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.