Back to discover
Disease

Bundle-Branch Block

Active therapeutic pipelineEmerging research
MeSHBundle-Branch Block
1
Publications
16
Clinical trials
7
Associated genes
2
Related proteins
2005
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q3 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutImportant
Left Bundle Branch Pacing as Initial Therapy in Patients With Non-ischemic Heart Failure and Left Bundle Branch Block (LIT-HF Study)
Results expected Q4 20272026-05-14
Upcoming trial readoutImportant
His-Bundle Corrective Pacing in Heart Failure
Results expected Q3 20272026-02-09
Clinical Milestones2View
Results expected 2
Activity timeline2

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Tenecteplaseapproved

Approval — Metalyse is indicated for the thrombolytic treatment of suspected myocardial infarction w… (2001)

Clinical trials

14 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
16
All trials
6
Active
0
Late-stage
3
Completed
Recruiting

His-Bundle Corrective Pacing in Heart Failure

N/A · Recruiting · University of Rochester

Comparison of Early Ambulatory Monitoring Strategy Versus Electrophysiological Study Approach in the Management of Patients With New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation

N/A · Recruiting · Assistance Publique Hopitaux De Marseille

Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI)

N/A · Recruiting · Montreal Heart Institute

Randomized Study of Integrated Evaluation of Conventional Biventricular and Left Bundle Branch Pacing Therapy Effect on Left Ventricular Remodeling and Clinical Outcomes in Patients With Chronic Heart Failure With Reduced Ejection Fraction

N/A · Recruiting · Tomsk National Research Medical Center of the Russian Academy of Sciences

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals
2001emaApproval — Tenecteplase· Metalyse is indicated for the thrombolytic treatment of suspected myocardial infarction with persistent ST elevation or recent left-bundle-branch block within six hours after the onset of acute-myocardial-infarction symptoms. Metalyse is indicated in adults for the thrombolytic treatment of acute ischaemic stroke (AIS) within 4.5 hours from last known well and after exclusion of intracranial haemorrhage. source ↗
Safety updates
2024emaMarket withdrawal — Reteplase· Rapilysin is indicated for the thrombolytic treatment of suspected myocardial infarction with persistent ST elevation or recent left bundle branch block within 12 hours after the onset of acute-myocardial-infarction (AMI) symptoms. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes1
  • Electrocardiography1
Leading journals1
  • Circulation1
Leading researchers8
  • Antzelevitch C1
  • Borggrefe M1
  • Brugada J1
  • Brugada P1
  • Brugada R1
  • Corrado D1
  • Gussak I1
  • LeMarec H1
Affiliations (unnormalised)1
  • Masonic Medical Research Laboratory1

Associated genes

7 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

SCN5A0.80CCDC1410.39PPARGC1A0.38UGT80.37MEF2D0.26TRPM40.15FKBP70.06

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Sodium channel protein type 5 subunit alphavia SCN5A0.80Peroxisome proliferator-activated receptor gamma coactivator 1-alphavia PPARGC1A0.38

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.

Identifiers
MeSHBundle-Branch Block
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.