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Disease

Bundle-Branch Block

Active therapeutic pipelineEmerging research
MeSHBundle-Branch Block
1
Publications
13
Clinical trials
2005
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Clinical Milestones2View
Results expected 2
Activity timeline2

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
13
All trials
5
Active
0
Late-stage
2
Completed
Recruiting

Comparison of Early Ambulatory Monitoring Strategy Versus Electrophysiological Study Approach in the Management of Patients With New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation

N/A · Recruiting · Assistance Publique Hopitaux De Marseille

Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI)

N/A · Recruiting · Montreal Heart Institute

Randomized Study of Integrated Evaluation of Conventional Biventricular and Left Bundle Branch Pacing Therapy Effect on Left Ventricular Remodeling and Clinical Outcomes in Patients With Chronic Heart Failure With Reduced Ejection Fraction

N/A · Recruiting · Tomsk National Research Medical Center of the Russian Academy of Sciences

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

Safety updates
2024emaMarket withdrawal — Reteplase· Rapilysin is indicated for the thrombolytic treatment of suspected myocardial infarction with persistent ST elevation or recent left bundle branch block within 12 hours after the onset of acute-myocardial-infarction (AMI) symptoms. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes1
  • Electrocardiography1
Leading journals1
  • Circulation1
Leading researchers8
  • Antzelevitch C1
  • Borggrefe M1
  • Brugada J1
  • Brugada P1
  • Brugada R1
  • Corrado D1
  • Gussak I1
  • LeMarec H1
Affiliations (unnormalised)1
  • Masonic Medical Research Laboratory1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.

Identifiers
MeSHBundle-Branch Block
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.