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PPARGC1A

Gene

PPARG coactivator 1 alpha

HGNCHGNC:9237EnsemblENSG00000109819NCBI Gene10891
Locus: gene with protein productLocation: 4p15.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Peroxisome proliferator-activated receptor gamma coactivator 1-alphaQ9UBK2

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPPARGC1 · PGC1 · PGC1A · PGC-1alpha · PPARAGCIα
View full nomenclature history (9)
Previous symbolsPPARGC1
Alias symbolsPGC1, PGC1A, PGC-1alpha, PPARAGCIα
Previous namesperoxisome proliferator-activated receptor gamma, coactivator 1 alpha, peroxisome proliferative activated receptor, gamma, coactivator 1, peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
Alias namesPPARgamma coactivator 1alpha

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Amyotrophic Lateral Sclerosis
Smoking initiation
Bundle-Branch Block
Renal Insufficiency
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

RNA binding motif containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.